Effects of autonomic blockade on non-linear cardiovascular variability indices in rats

被引:66
作者
Beckers, F
Verheyden, B
Ramaekers, D
Swynghedauw, B
Aubert, AE
机构
[1] Katholieke Univ Leuven, Lab Expt Cardiol, Sch Med, Univ Hosp Gasthuisberg, Louvain, Belgium
[2] Hop Lariboisiere, INSERM, U572, F-75475 Paris, France
关键词
autonomic nervous system; baroreflex; blood pressure; heart rate variability;
D O I
10.1111/j.1440-1681.2006.04384.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The present study assesses the effects of autonomic blockade (alpha- and beta-adrenoceptor and cholinergic) on cardiovascular function studied by heart rate variability (HRV), blood pressure variability (BPV) and baroreflex sensitivity in rats using non-linear dynamics. Little is known about the influence of pharmacological autonomic nervous system interventions on non-linear cardiovascular regulatory indices. 2. In 13 conscious rats, heart rate and aortic blood pressure were measured continuously before, during and after autonomic blockade with atropine, phentolamine and propranolol. Non-linear scaling properties were studied using 1/f slope, fractal dimension and long- and short-term correlation. Non-linear complexity was described with correlation dimension, Lyapunov exponent and approximate entropy. Non-linear indices were compared with linear time and frequency domain indices. 3. beta-Adrenoceptor blockade did not alter the non-linear characteristics of HRV and BPV, although low-frequency power of HRV was depressed. alpha-Adrenoceptor blockade decreased the scaling behaviour of HRV, whereas cholinergic blockade decreased the complexity of the non-linear system of HRV. For BPV, the scaling behaviour was increased during a-adrenoceptor blockade and the complexity was increased during cholinergic blockade. The linear indices of HRV and BPV were decreased. 4. The present results indicate that the beta-adrenoceptor system has little involvement in the generation of non-linear HRV and BPV in rats. 5. alpha-Adrenoceptor blockade mostly influenced the scaling properties of the time series, whereas cholinergic blockade induced changes in the complexity measures. 6. The absence of the baroreflex mechanism can trigger a compensatory feed-forward system increasing the complexity of BPV.
引用
收藏
页码:431 / 439
页数:9
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