Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man

被引：24

作者：

Roy, PM ^{[1
]}

Gouello, JP ^{[1
]}

Pennison-Besnier, I ^{[1
]}

Chennebault, JM ^{[1
]}

机构：

[1] Univ Hosp, Dept Emergency Med, Angers, France

来源：

ANNALS OF EMERGENCY MEDICINE | 1999年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(99)70244-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.

引用

页码：282 / 284

页数：3

共 12 条

[1] FULMINANT-HEPATITIS WITH SEVERE LACTATE ACIDOSIS IN HIV-INFECTED PATIENTS ON DIDANOSINE THERAPY
BISSUEL, F
BRUNEEL, F
HABERSETZER, F
CHASSARD, D
COTTE, L
CHEVALLIER, M
BERNUAU, J
LUCET, JC
TREPO, C
[J]. JOURNAL OF INTERNAL MEDICINE, 1994, 235 (04) : 367 - 371
[2] DETERMINATION OF THE BLOOD LACTATE-PYRUVATE RATIO AS A NONINVASIVE TEST FOR THE DIAGNOSIS OF ZIDOVUDINE MYOPATHY
CHARIOT, P
MONNET, I
MOUCHET, M
ROHR, M
LEFAUCHEUR, JP
DUBREUILLEMAIRE, ML
CHOUSTERMAN, M
GHERARDI, R
[J]. ARTHRITIS AND RHEUMATISM, 1994, 37 (04): : 583 - 586
[3] CHEN CH, 1991, MOL PHARMACOL, V39, P625
[4] HEPATOMEGALY WITH SEVERE STEATOSIS IN HIV-SEROPOSITIVE PATIENTS
FREIMAN, JP
HELFERT, KE
HAMRELL, MR
STEIN, DS
[J]. AIDS, 1993, 7 (03) : 379 - 385
[5] GOPINATH R, 1992, J AM SOC NEPHROL, V3, P1212
[6] HIGH-OUTPUT HEART-FAILURE IN MITOCHONDRIAL MYOPATHY - A FULMINANT FORM WITH SEVERE LACTIC-ACIDOSIS AND RHABDOMYOLYSIS
HIROSE, Y
MIIDA, T
YOSHIDA, K
KIMURA, H
ODA, H
TOEDA, T
HIGUMA, N
[J]. INTERNAL MEDICINE, 1993, 32 (10) : 798 - 801
[7] Mitochondrial injury - Lessons from the fialuridine trial
Honkoop, P
Scholte, HR
deMan, RA
Schalm, SW
[J]. DRUG SAFETY, 1997, 17 (01) : 1 - 7
[8] Meurin P, 1996, PRESSE MED, V25, P1115
[9] ZIDOVUDINE MYOPATHY - A DISTINCTIVE DISORDER ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION
MHIRI, C
BAUDRIMONT, M
BONNE, G
GENY, C
DEGOUL, F
MARSAC, C
ROULLET, E
GHERARDI, R
[J]. ANNALS OF NEUROLOGY, 1991, 29 (06) : 606 - 614
[10] LACTIC-ACIDOSIS IN CRITICAL ILLNESS
MIZOCK, BA
FALK, JL
[J]. CRITICAL CARE MEDICINE, 1992, 20 (01) : 80 - 93

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