Low-cost modification of a contact atomic force microscope (AFM) into a sound-activated tapping mode AFM for use in air and liquids

被引：9

作者：

Vinckier, A ^{[1
]}

Hennau, F ^{[1
]}

Kjoller, K ^{[1
]}

Hellemans, L ^{[1
]}

机构：

[1] DIGITAL INSTRUMENTS INC, SANTA BARBARA, CA 93103 USA

来源：

REVIEW OF SCIENTIFIC INSTRUMENTS | 1996年 / 67卷 / 02期

关键词：

D O I：

10.1063/1.1146601

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Tapping mode capabilities are successfully implemented on a commercial contact mode atomic force microscope. In our setup, standard Si3N4 cantilevers are vibrated by an acoustic wave from a small piezo speaker. The minor changes needed in the measurement electronics are presented. Experiments performed both in air and under liquid, on hard as well as on soft samples, clearly demonstrate improvements in image quality, contrast, and resolution. Especially on soft biological samples, such as microtubules, the common problems of smearing and irreversible sample damage by scanning seem to be alleviated. (C) 1996 American Institute of Physics.

引用

收藏

页码：387 / 392

页数：6

相关论文

共 27 条

[1] AN ATOMIC-RESOLUTION ATOMIC-FORCE MICROSCOPE IMPLEMENTED USING AN OPTICAL-LEVER [J].

ALEXANDER, S ;

HELLEMANS, L ;

MARTI, O ;

SCHNEIR, J ;

ELINGS, V ;

HANSMA, PK ;

LONGMIRE, M ;

GURLEY, J .

JOURNAL OF APPLIED PHYSICS, 1989, 65 (01) :164-167

[2] ADSORPTION OF DNA TO MICA, SILYLATED MICE, AND MINERALS - CHARACTERIZATION BY ATOMIC-FORCE MICROSCOPY [J].

BEZANILLA, M ;

MANNE, S ;

LANEY, DE ;

LYUBCHENKO, YL ;

HANSMA, HG .

LANGMUIR, 1995, 11 (02) :655-659

[3] MOTION AND ENZYMATIC DEGRADATION OF DNA IN THE ATOMIC-FORCE MICROSCOPE [J].

BEZANILLA, M ;

DRAKE, B ;

NUDLER, E ;

KASHLEV, M ;

HANSMA, PK ;

HANSMA, HG .

BIOPHYSICAL JOURNAL, 1994, 67 (06) :2454-2459

[4] ATOMIC FORCE MICROSCOPE [J].

BINNIG, G ;

QUATE, CF ;

GERBER, C .

PHYSICAL REVIEW LETTERS, 1986, 56 (09) :930-933

[5]

ENGEL A, 1991, ANNU REV BIOPHYS BIO, V20, P79, DOI 10.1146/annurev.biophys.20.1.79

[6] KINETIC-ANALYSIS OF ASSEMBLY OF MICROTUBULES INVITRO [J].

ENGELBORGHS, Y ;

DEMAEYER, LCM ;

OVERBERGH, N .

FEBS LETTERS, 1977, 80 (01) :81-85

[7]

GUTHNER P, 1989, APPL PHYS B, V48, P89

[8] BIOMOLECULAR IMAGING WITH THE ATOMIC-FORCE MICROSCOPE [J].

HANSMA, HG ;

HOH, JH .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1994, 23 :115-139

[9] TAPPING MODE ATOMIC-FORCE MICROSCOPY IN LIQUIDS [J].

HANSMA, PK ;

CLEVELAND, JP ;

RADMACHER, M ;

WALTERS, DA ;

HILLNER, PE ;

BEZANILLA, M ;

FRITZ, M ;

VIE, D ;

HANSMA, HG ;

PRATER, CB ;

MASSIE, J ;

FUKUNAGA, L ;

GURLEY, J ;

ELINGS, V .

APPLIED PHYSICS LETTERS, 1994, 64 (13) :1738-1740

[10] COVALENT BINDING OF BIOLOGICAL SAMPLES TO SOLID SUPPORTS FOR SCANNING PROBE MICROSCOPY IN BUFFER SOLUTION [J].

KARRASCH, S ;

DOLDER, M ;

SCHABERT, F ;

RAMSDEN, J ;

ENGEL, A .

BIOPHYSICAL JOURNAL, 1993, 65 (06) :2437-2446