Asymmetric organocatalytic Henry reaction

被引：300

作者：

Marcelli, T ^{[1
]}

van der Haas, RNS ^{[1
]}

van Maarseveen, JH ^{[1
]}

Hiemstra, H ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1018 WS Amsterdam, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 06期

关键词：

alkaloids; asymmetric catalysis; Henry reaction; hydrogen bonds; organocatalysis;

D O I：

10.1002/anie.200503724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The nitroaldol (Henry) reaction between aromatic aldehydes and nitromethane can be carried out in high yields and enantiomeric excess by using a novel Cinchona-derived thiourea catalyst. Hydrogen-bond donors at the C6′ position in these organocatalysts are shown to induce preferential formation of one enantiomer. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：929 / 931

页数：3

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