Molecular Alterations and Biomarkers in Colorectal Cancer

被引：96

作者：

Grady, William M. ^{[1
,2
]}

Pritchard, Colin C. ^{[3
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA USA

[3] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

来源：

TOXICOLOGIC PATHOLOGY | 2014年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

biomarkers; BRAF; cetuximab; chromosome instability; colon cancer; EGFR; KRAS; microsatellite instability; MSI; panitumumab; ISLAND METHYLATOR PHENOTYPE; III COLON-CANCER; MICROSATELLITE INSTABILITY PREDICTS; CETUXIMAB PLUS IRINOTECAN; FACTOR-BETA RECEPTOR; MISMATCH-REPAIR; BRAF MUTATIONS; STOOL DNA; STAGE-II; 5-FLUOROURACIL-BASED CHEMOTHERAPY;

D O I：

10.1177/0192623313505155

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

The promise of precision medicine is now a clinical reality. Advances in our understanding of the molecular genetics of colorectal cancer (CRC) are leading to the development of a variety of biomarkers that are being used as early detection markers, prognostic markers, and markers for predicting treatment responses. This is no more evident than in the recent advances in testing CRCs for specific molecular alterations in order to guide treatment with the monoclonal antibody therapies cetuximab and panitumumab, which target the epidermal growth factor receptor. In this review, we update a prior review published in 2010 and describe our current understanding of the molecular pathogenesis of CRC and how these alterations relate to emerging biomarkers for early detection and risk stratification (diagnostic markers), prognosis (prognostic markers), and the prediction of treatment responses (predictive markers).

引用

页码：124 / 139

页数：16

共 133 条

[1]

AHLQUIST DA, 1993, NEW ENGL J MED, V329, P1351

[2]

Stool DNA and occult blood testing for screen detection of colorectal neoplasia [J].

Ahlquist, David A. ;

Sargent, Daniel J. ;

Loprinzi, Charles L. ;

Levin, Theodore R. ;

Rex, Douglas K. ;

Ahnen, Dennis J. ;

Knigge, Kandice ;

Lance, Peter ;

Burgart, Lawrence J. ;

Hamilton, Stanley R. ;

Allison, James E. ;

Lawson, Michael J. ;

Devens, Mary E. ;

Harrington, Jonathan J. ;

Hillman, Shauna L. .

ANNALS OF INTERNAL MEDICINE, 2008, 149 (07) :441-W81

[3]

SMAD4 as a prognostic marker in colorectal cancer [J].

Alazzouzi, H ;

Alhopuro, P ;

Salovaara, R ;

Sammalkorpi, H ;

Järvinen, H ;

Mecklin, JP ;

Hemminki, A ;

Schwartz, S ;

Aaltonen, LA ;

Arango, D .

CLINICAL CANCER RESEARCH, 2005, 11 (07) :2606-2611

[4]

Histopathological identification of colon cancer with microsatellite instability [J].

Alexander, J ;

Watanabe, T ;

Wu, TT ;

Rashid, A ;

Li, SA ;

Hamilton, SR .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (02) :527-535

[5]

SMAD4 levels and response to 5-fluorouracil in colorectal cancer [J].

Alhopuro, P ;

Alazzouzi, H ;

Sammalkorpi, H ;

Dávalos, V ;

Salovaara, R ;

Hemminki, A ;

Järvinen, H ;

Mecklin, JP ;

Schwartz, S ;

Aaltonen, LA ;

Arango, D .

CLINICAL CANCER RESEARCH, 2005, 11 (17) :6311-6316

[6]

American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy [J].

Allegra, Carmen J. ;

Jessup, J. Milburn ;

Somerfield, Mark R. ;

Hamilton, Stanley R. ;

Hammond, Elizabeth H. ;

Hayes, Daniel F. ;

McAllister, Pamela K. ;

Morton, Roscoe F. ;

Schilsky, Richard L. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (12) :2091-2096

[7]

Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].

Amado, Rafael G. ;

Wolf, Michael ;

Peeters, Marc ;

Van Cutsem, Eric ;

Siena, Salvatore ;

Freeman, Daniel J. ;

Juan, Todd ;

Sikorski, Robert ;

Suggs, Sid ;

Radinsky, Robert ;

Patterson, Scott D. ;

Chang, David D. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634

[8]

WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[9]

[Anonymous], 2008, J CLIN ONCOL S

[10]

Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer [J].

Artale, Salvatore ;

Sartore-Bianchi, Andrea ;

Veronese, Silvio Marco ;

Gambi, Valentina ;

Sarnataro, Carolina Silvia ;

Gambacorta, Marcello ;

Lauricella, Calogero ;

Siena, Salvatore .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (25) :4217-4219

← 1 2 3 4 5 6 7 8 9 10 →