Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

被引：72

作者：

Allard, Pierre-Marie ^{[1
]}

Leyssen, Pieter ^{[2
]}

Martin, Marie-Therese ^{[1
]}

Bourjot, Melanie ^{[1
]}

Dumontet, Vincent ^{[1
]}

Eydoux, Cecilia ^{[3
]}

Guillemot, Jean-Claude ^{[3
]}

Canard, Bruno ^{[3
]}

Poullain, Cyril ^{[1
]}

Gueritte, Francoise ^{[1
]}

Litaudon, Marc ^{[1
]}

机构：

[1] CNRS, LabEx LERMIT, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

[2] Katholieke Univ Leuven, Rega Inst Med Res, Lab Virol & Expt Chemotherapy, B-3000 Louvain, Belgium

[3] AFMB Aix Marseille Univ UMR7257, Lab Architecture & Fonct Macromol Biol, F-13288 Marseille, France

来源：

PHYTOCHEMISTRY | 2012年 / 84卷

关键词：

Trigonostemon cherrieri; Euphorbiaceae; Trigocherrin; Trigocherriolide; Daphnane; Chlorinated diterpenes; Antiviral; Chikungunya virus; Sindbis virus; Semliki forest virus; Dengue virus; PLANT; CONSTITUENTS;

D O I：

10.1016/j.phytochem.2012.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical study of the bark and the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A-F and trigocherriolides A-D. Herein, we describe the isolation and structure elucidation of the DDO (trigocherrins B-F and trigocherriolides A-D). We also report the antiviral activity of trigocherrins A, B and F (1, 2 and 6) and trigocherriolides A, B and C (7-9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) and dengue virus (DENV). (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：160 / 168

页数：9

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