Efficient nucleophilic substitution reactions of quinolyl and isoquinolyl halides with nucleophiles under focused microwave irradiation

被引：32

作者：

Cherng, YJ ^{[1
]}

机构：

[1] Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung 40605, Taiwan

来源：

TETRAHEDRON | 2002年 / 58卷 / 06期

关键词：

nucleophilic substitution reaction;

D O I：

10.1016/S0040-4020(01)01225-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic substitution reactions of 2-chloroquinoline, 3-bromoquinoline and 4-bromoisoquinoline with thiolate, alkoxy ions and aniline were completed within several minutes under microwave irradiation. This method gives the desired products with yields up to 99% in a short reaction time, and is superior to the classical heating process. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1125 / 1129

页数：5

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