Current understanding of HIF in renal disease

被引：25

作者：

Rosenberger, C

Rosen, S

Heyman, SN

机构：

[1] Charite Univ Clin, DE-13353 Berlin, Germany

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[4] Hebrew Univ Jerusalem, Sch Med, Jerusalem, Israel

[5] Hadassah Hosp Mt Scopus, Dept Med, Jerusalem, Israel

来源：

KIDNEY & BLOOD PRESSURE RESEARCH | 2005年 / 28卷 / 5-6期

关键词：

hypoxia-inducible factors; prolyl-hydroxylase inhibition; p53; acute renal failure; renal interstitial fibrosis;

D O I：

10.1159/000090187

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Hypoxia-inducible factors (HIF) are ubiquitous transcription factors regulated by oxygen-dependent proteolysis, and hence rapidly mount an adaptational response to hypoxia. The HIF system is apparently more complex than initially considered in the perspective of the increasing number of HIF target genes, and the interrelationship with various additional regulatory pathways. Regional hypoxia is believed to play a major role in renal disease. Experimental data confirm a role for HIF in renal pathophysiology. The discovery of HIF prolyl-hydroxylases as key enzymes of oxygen sensing and HIF proteolysis offer new possibilities to therapeutically target HIF. Herein, we review basic concepts of HIF regulation, and existing data on HIF activation in renal disease. Copyright (c) 2005 S. Karger AG, Basel.

引用

页码：325 / 340

页数：16

共 146 条

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