Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (Jaspine B) from D-xylose

被引：57

作者：

Du, YG ^{[1
]}

Liu, J

Linhardt, RJ

机构：

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[2] Rensselaer Polytech Inst, Dept Chem, Troy, NY 12180 USA

[3] Rensselaer Polytech Inst, Dept Biol, Troy, NY 12180 USA

[4] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 03期

关键词：

D O I：

10.1021/jo051644y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first naturally occurring anhydrophytosphingosine, pachastrissamine (jaspine B), a marine compound cytotoxic toward P388, A549, HT29, and MEL28 cell lines at IC50 = 0.01 μg/mL level, has been stereoselectively synthesized from D-xylose in 10 linear steps with 25.7% overall yield. © 2006 American Chemical Society.

引用

页码：1251 / 1253

页数：3

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