Regional specialization in the mucosal immune system: primed cells do not always home along the same track

被引：216

作者：

Brandtzaeg, P ^{[1
]}

Farstad, IN ^{[1
]}

Haraldsen, G ^{[1
]}

机构：

[1] Univ Oslo, Natl Hosp, Inst Pathol, LIPAT, N-0027 Oslo, Norway

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(99)01468-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha(4)beta(7), which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.

引用

页码：267 / 277

页数：11

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