Regional specialization in the mucosal immune system: primed cells do not always home along the same track

被引：216

作者：

Brandtzaeg, P ^{[1
]}

Farstad, IN ^{[1
]}

Haraldsen, G ^{[1
]}

机构：

[1] Univ Oslo, Natl Hosp, Inst Pathol, LIPAT, N-0027 Oslo, Norway

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(99)01468-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha(4)beta(7), which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.

引用

页码：267 / 277

页数：11

共 113 条

[91]

Rott LS, 1996, J IMMUNOL, V156, P3727

[92] Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses [J].

Sallusto, F ;

Lanzavecchia, A ;

Mackay, CR .

IMMUNOLOGY TODAY, 1998, 19 (12) :568-574

[93] DUAL BINDING-CAPACITY OF MUCOSAL IMMUNOBLASTS TO MUCOSAL AND SYNOVIAL ENDOTHELIUM IN HUMANS - DISSECTION OF THE MOLECULAR MECHANISMS [J].

SALMI, M ;

ANDREW, DP ;

BUTCHER, EC ;

JALKANEN, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :137-149

[94] ABERRANT BINDING OF LAMINA PROPRIA LYMPHOCYTES TO VASCULAR ENDOTHELIUM IN INFLAMMATORY BOWEL DISEASES [J].

SALMI, M ;

GRANFORS, K ;

MACDERMOTT, R ;

JALKANEN, S .

GASTROENTEROLOGY, 1994, 106 (03) :596-605

[95]

Shyjan AM, 1996, J IMMUNOL, V156, P2851

[96] Long-lived plasma cells: a mechanism for maintaining persistent antibody production [J].

Slifka, MK ;

Ahmed, R .

CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (03) :252-258

[97]

SMINIA T, 1989, CRIT REV IMMUNOL, V9, P119

[98] TRAFFIC SIGNALS ON ENDOTHELIUM FOR LYMPHOCYTE RECIRCULATION AND LEUKOCYTE EMIGRATION [J].

SPRINGER, TA .

ANNUAL REVIEW OF PHYSIOLOGY, 1995, 57 :827-872

[99]

Steffen BJ, 1996, AM J PATHOL, V148, P1819

[100] A TISSUE-SPECIFIC ENDOTHELIAL-CELL MOLECULE INVOLVED IN LYMPHOCYTE HOMING [J].

STREETER, PR ;

BERG, EL ;

ROUSE, BTN ;

BARGATZE, RF ;

BUTCHER, EC .

NATURE, 1988, 331 (6151) :41-46

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