Regional specialization in the mucosal immune system: primed cells do not always home along the same track

被引：216

作者：

Brandtzaeg, P ^{[1
]}

Farstad, IN ^{[1
]}

Haraldsen, G ^{[1
]}

机构：

[1] Univ Oslo, Natl Hosp, Inst Pathol, LIPAT, N-0027 Oslo, Norway

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(99)01468-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha(4)beta(7), which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.

引用

页码：267 / 277

页数：11

共 113 条

[21] Epidemiological typing of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates responsible for five outbreaks in a university hospital [J].

Branger, C ;

Bruneau, B ;

Lesimple, AL ;

Bouvet, PJM ;

Berry, P ;

SevaliGarcia, J ;

LambertZechovsky, N .

JOURNAL OF HOSPITAL INFECTION, 1997, 36 (01) :23-36

[22]

BRANTON P, 1987, INT REV ERGON, V1, P1

[23]

Briskin M, 1997, AM J PATHOL, V151, P97

[24] Lymphocyte homing and homeostasis [J].

Butcher, EC ;

Picker, LJ .

SCIENCE, 1996, 272 (5258) :60-66

[25] 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7 [J].

Campbell, JJ ;

Bowman, EP ;

Murphy, K ;

Youngman, KR ;

Siani, MA ;

Thompson, DA ;

Wu, LJ ;

Zlotnik, A ;

Butcher, EC .

JOURNAL OF CELL BIOLOGY, 1998, 141 (04) :1053-1059

[26] Chemokines and the arrest of lymphocytes rolling under flow conditions [J].

Campbell, JJ ;

Hedrick, J ;

Zlotnik, A ;

Siani, MA ;

Thompson, DA ;

Butcher, EC .

SCIENCE, 1998, 279 (5349) :381-384

[27] A MONOCLONAL-ANTIBODY (HML-1) DEFINING A NOVEL MEMBRANE MOLECULE PRESENT ON HUMAN INTESTINAL LYMPHOCYTES [J].

CERFBENSUSSAN, N ;

JARRY, A ;

BROUSSE, N ;

LISOWSKAGROSPIERRE, B ;

GUYGRAND, D ;

GRISCELLI, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (09) :1279-1285

[28] PEYERS PATCHES - ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN RABBIT [J].

CRAIG, SW ;

CEBRA, JJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1971, 134 (01) :188-&

[29] Rectal immunization for induction of specific antibody in the genital tract of women [J].

CrowleyNowick, PA ;

Bell, MC ;

Brockwell, R ;

Edwards, RP ;

Chen, S ;

Partridge, EE ;

Mestecky, J .

JOURNAL OF CLINICAL IMMUNOLOGY, 1997, 17 (05) :370-379

[30] DEVELOPMENTAL RELATIONSHIP BETWEEN CYTOTOXIC ALPHA/BETA T-CELL RECEPTOR-POSITIVE INTRAEPITHELIAL LYMPHOCYTES AND PEYER PATCH LYMPHOCYTES [J].

CUFF, CF ;

CEBRA, CK ;

RUBIN, DH ;

CEBRA, JJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (06) :1333-1339

← 1 2 3 4 5 6 7 8 9 10 →