Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative diseases

被引：18

作者：

Westman-Brinkmalm, Ann ^{[1
]}

Ruetschi, Ulla ^{[2
]}

Portelius, Erik ^{[1
]}

Andreasson, Ulf ^{[1
]}

Brinkmalm, Gunnar ^{[1
]}

Karlsson, Gosta ^{[1
]}

Hansson, Sara ^{[1
]}

Zetterberg, Henrik ^{[1
]}

Blennow, Kaj ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, S-43180 Molndal, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Clin Chem & Transfus Med, Inst Lab Med, S-43180 Molndal, Sweden

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

基金：

瑞典研究理事会;

关键词：

Alzheimer's disease; Frontotemporal Dementia; Cerebrospinal Fluid; Multiple Sclerosis; Proteomics; Review; LASER-DESORPTION/IONIZATION-TIME; FLIGHT-MASS-SPECTROMETRY; HUMAN CEREBROSPINAL-FLUID; ONSET ALZHEIMER-DISEASE; AMYLOID-BETA PEPTIDES; 2-DIMENSIONAL GEL-ELECTROPHORESIS; MILD COGNITIVE IMPAIRMENT; APOLIPOPROTEIN-E GENOTYPE; MULTIPLE-SCLEROSIS; FRONTOTEMPORAL DEMENTIA;

D O I：

10.2741/3341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurodegenerative diseases are characterized by premature neuronal loss in specific brain regions. During the past decades our knowledge on molecular mechanisms underlying neurodegeneration has increased immensely and resulted in promising drug candidates that might slow down or even stop the neuronal loss. These advances have put a strong focus on the development of diagnostic tools for early or pre-clinical detection of the disorders. In this review we discuss our experience in the field of neuroproteomics/peptidomics, with special focus on biomarker discovery studies that have been performed on CSF samples from well-defined patient and control populations.

引用

收藏

页码：1793 / 1806

页数：14

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