Recentadvances in the development of peptide nucleic acid as a gene-targeted drug

被引：40

作者：

Marin, VL ^{[1
]}

Roy, S ^{[1
]}

Armitage, BA ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2004年 / 4卷 / 03期

关键词：

antigene; antisense; gene expression; hybridisation; peptide nucleic acid; PNA; telomerase; therapeutics;

D O I：

10.1517/14712598.4.3.337

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide nucleic acid (PNA) is a non-ionic mimic of DNA that binds to complementary DNA and RNA sequences with high affinity and selectivity. Targeting of single-stranded RNA leads,to antisense effects, whereas PNAs directed toward double-stranded DNA exhibit antigene properties. Recent advances in cell uptake and in antisense and antigene effects in biological systems are summarised in this review. in addition to traditional targets, namely genomic DNA and messenger RNA, applications for PNA as a bacteriocidal antibiotic, for regulating splice site selection and as a telomerase inhibitor are described.

引用

页码：337 / 348

页数：12

共 107 条

[41]

Heckl S, 2003, CANCER RES, V63, P4766

[42] Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death [J].

Herbert, BS ;

Pitts, AE ;

Baker, SI ;

Hamilton, SE ;

Wright, WE ;

Shay, JW ;

Corey, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (25) :14276-14281

[43] Deletion of individual exons and induction of soluble murine interleukin-5 receptor-α chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing [J].

Karras, JG ;

McKay, RA ;

Dean, NM ;

Monia, BP .

MOLECULAR PHARMACOLOGY, 2000, 58 (02) :380-387

[44] Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-α chain [J].

Karras, JG ;

Maier, MA ;

Lu, T ;

Watt, A ;

Manoharan, M .

BIOCHEMISTRY, 2001, 40 (26) :7853-7859

[45] Antisense properties of duplex- and triplex-forming PNAs [J].

Knudsen, H ;

Nielsen, PE .

NUCLEIC ACIDS RESEARCH, 1996, 24 (03) :494-500

[46] Cellular delivery of peptide nucleic acid (PNA) [J].

Koppelhus, U ;

Nielsen, PE .

ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (02) :267-280

[47] Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates [J].

Koppelhus, U ;

Awasthi, SK ;

Zachar, V ;

Holst, HU ;

Ebbesen, P ;

Nielsen, PE .

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 2002, 12 (02) :51-63

[48] Identification of novel genes coding for small expressed RNAs [J].

Lagos-Quintana, M ;

Rauhut, R ;

Lendeckel, W ;

Tuschl, T .

SCIENCE, 2001, 294 (5543) :853-858

[49] Preparation of avidin-labeled protein nanoparticles as carriers for biotinylated peptide nucleic acid [J].

Langer, K ;

Coester, C ;

Weber, C ;

von Briesen, H ;

Kreuter, J .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 49 (03) :303-307

[50] An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans [J].

Lau, NC ;

Lim, LP ;

Weinstein, EG ;

Bartel, DP .

SCIENCE, 2001, 294 (5543) :858-862

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