Recentadvances in the development of peptide nucleic acid as a gene-targeted drug

被引：40

作者：

Marin, VL ^{[1
]}

Roy, S ^{[1
]}

Armitage, BA ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2004年 / 4卷 / 03期

关键词：

antigene; antisense; gene expression; hybridisation; peptide nucleic acid; PNA; telomerase; therapeutics;

D O I：

10.1517/14712598.4.3.337

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide nucleic acid (PNA) is a non-ionic mimic of DNA that binds to complementary DNA and RNA sequences with high affinity and selectivity. Targeting of single-stranded RNA leads,to antisense effects, whereas PNAs directed toward double-stranded DNA exhibit antigene properties. Recent advances in cell uptake and in antisense and antigene effects in biological systems are summarised in this review. in addition to traditional targets, namely genomic DNA and messenger RNA, applications for PNA as a bacteriocidal antibiotic, for regulating splice site selection and as a telomerase inhibitor are described.

引用

页码：337 / 348

页数：12

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