The influence of G-quadruplex structure on DNA-based asymmetric catalysis using the G-quadruplex-bound cationic porphyrin TMPyP4•Cu

被引：57

作者：

Wilking, Michael ^{[1
]}

Hennecke, Ulrich ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 40期

关键词：

TELOMERIC G-QUADRUPLEX; HYDRATION;

D O I：

10.1039/c3ob41366g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The DNA G-quadruplex-binding porphyrin TMPyP4 center dot Cu was found to form efficient hybrid catalysts for DNA-based asymmetric catalysis when bound to DNA G-quadruplexes. Nucleobase substitution experiments using human telomere-derived G-quadruplex sequences suggest binding of the porphyrin on the 3'-face.

引用

页码：6940 / 6945

页数：6

共 44 条

[41] Enantioselective Friedel-Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme [J].

Wang, Changhao ;

Li, Yinghao ;

Jia, Guoqing ;

Liu, Yan ;

Lu, Shengmei ;

Li, Can .

CHEMICAL COMMUNICATIONS, 2012, 48 (50) :6232-6234

[42] SOLUTION STRUCTURE OF THE HUMAN TELOMERIC REPEAT D[AG(3)(T(2)AG(3))3] G-TETRAPLEX [J].

WANG, Y ;

PATEL, DJ .

STRUCTURE, 1993, 1 (04) :263-282

[43] MOLECULAR STRUCTURE OF NUCLEIC ACIDS - A STRUCTURE FOR DEOXYRIBOSE NUCLEIC ACID [J].

WATSON, JD ;

CRICK, FHC .

NATURE, 1953, 171 (4356) :737-738

[44] Evidence for the binding mode of porphyrins to G-quadruplex DNA [J].

Wei, Chunying ;

Jia, Guoqing ;

Zhou, Jun ;

Han, Gaoyi ;

Li, Can .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2009, 11 (20) :4025-4032

← 1 2 3 4 5 →