The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila

被引：165

作者：

Franke, A ^{[1
]}

Baker, BS ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

MOLECULAR CELL | 1999年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(00)80193-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rox1 and rox2 RNAs have been suggested to be components of the dosage compensation machinery in Drosophila. We show that both rox RNAs colocalize with the male-specific lethal proteins at hundreds of specific bands along the male X chromosome. The rox RNAs and MSL proteins also colocalize with the X chromosome in all somatic cells and are expressed in the same temporal pattern throughout development. Genetic analysis shows that the functions of the rox genes are redundant and required for the association of the MSL proteins with the male X chromosome. These data provide compelling evidence for a direct function of the rox RNAs in dosage compensation.

引用

页码：117 / 122

页数：6

共 35 条

[11] Franke A, 1996, DEVELOPMENT, V122, P2751
[12] FRANTZ GD, 1994, J NEUROSCI, V14, P472
[13] Gu WG, 1998, DEV GENET, V22, P56, DOI 10.1002/(SICI)1520-6408(1998)22:1<56::AID-DVG6>3.0.CO
[14] 2-6
[15] mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
Hilfiker, A
HilfikerKleiner, D
Pannuti, A
Lucchesi, JC
[J]. EMBO JOURNAL, 1997, 16 (08) : 2054 - 2060
[16] THE INACTIVE X-CHROMOSOME IN FEMALE MAMMALS IS DISTINGUISHED BY A LACK OF HISTONE-H4 ACETYLATION, A CYTOGENETIC MARKER FOR GENE-EXPRESSION
JEPPESEN, P
TURNER, BM
[J]. CELL, 1993, 74 (02) : 281 - 289
[17] EXPRESSION OF MSL-2 CAUSES ASSEMBLY OF DOSAGE COMPENSATION REGULATORS ON THE X-CHROMOSOMES AND FEMALE LETHALITY IN DROSOPHILA
KELLEY, RL
SOLOVYEVA, I
LYMAN, LM
RICHMAN, R
SOLOVYEV, V
KURODA, MI
[J]. CELL, 1995, 81 (06) : 867 - 877
[18] EQUALITY FOR X-CHROMOSOMES
KELLEY, RL
KURODA, MI
[J]. SCIENCE, 1995, 270 (5242) : 1607 - 1610
[19] OSKAR MESSENGER-RNA IS LOCALIZED TO THE POSTERIOR POLE OF THE DROSOPHILA OOCYTE
KIMHA, J
SMITH, JL
MACDONALD, PM
[J]. CELL, 1991, 66 (01) : 23 - 34
[20] The NTPase/helicase activities of Drosophila maleless, an essential factor in dosage compensation
Lee, CG
Chang, KA
Kuroda, MI
Hurwitz, J
[J]. EMBO JOURNAL, 1997, 16 (10) : 2671 - 2681

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