Comparative assessment of large-scale data sets of protein-protein interactions

被引：1726

作者：

von Mering, C

Krause, R

Snel, B

Cornell, M

Oliver, SG

Fields, S

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Cellzome AG, D-69117 Heidelberg, Germany

[3] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[4] Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA

[5] Univ Washington, Howard Hughes Med Inst, Dept Med, Seattle, WA 98195 USA

来源：

NATURE | 2002年 / 417卷 / 6887期

关键词：

D O I：

10.1038/nature750

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comprehensive protein-protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

引用

页码：399 / 403

页数：5

共 43 条

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