Immunization of non-human primates with DNA vaccines

被引：64

作者：

Liu, MA ^{[1
]}

McClements, W ^{[1
]}

Ulmer, JB ^{[1
]}

Shiver, J ^{[1
]}

Donnelly, J ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT VIRUS & CELL BIOL,W POINT,PA 19486

来源：

VACCINE | 1997年 / 15卷 / 08期

关键词：

DNA vaccines; primates; influenza virus; herpes simplex virus; HIV;

D O I：

10.1016/S0264-410X(96)00280-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pre-clinical efficacy of DNA vaccines has been demonstrated in a number of animal models, but more limited data exist regarding their immunogenicity in non-human primates. The studies described below demonstrate that DNA vaccines in reasonable dosages encoding a variety of viral proteins could result in the generation of antibodies, neutralizing antibodies, or cytotoxic T lymphocytes in primates. Furthermore, these responses could be boosted by repeat administration of the DNA vaccine. In an effort to assess the safety of such vaccines sera from primates was shown to lack anti-DNA antibodies. (C) 1997 Elsevier Science Ltd.

引用

页码：909 / 912

页数：4

共 7 条

[1] PRECLINICAL EFFICACY OF A PROTOTYPE DNA VACCINE - ENHANCED PROTECTION AGAINST ANTIGENIC DRIFT IN INFLUENZA-VIRUS [J].