Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila

被引：48

作者：

Alekseyenko, Artyom A. ^{[1
,2
]}

Ellison, Christopher E. ^{[3
]}

Gorchakov, Andrey A. ^{[1
,2
,4
]}

Zhou, Qi ^{[3
]}

Kaiser, Vera B. ^{[3
]}

Toda, Nick ^{[3
]}

Walton, Zaak ^{[3
]}

Peng, Shouyong ^{[1
]}

Park, Peter J. ^{[1
,5
]}

Bachtrog, Doris ^{[3
]}

Kuroda, Mitzi I. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[4] Inst Mol & Cell Biol, Novosibirsk 630090, Russia

[5] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2013年 / 27卷 / 08期

关键词：

dosage compensation; MSL complex; Drosophila; chromatin; MSL COMPLEX; X-CHROMOSOME; POSITIVE SELECTION; LETHAL COMPLEX; Y-CHROMOSOME; GENES; EVOLUTION; TRANSCRIPTION; RECRUITMENT; ADAPTATION;

D O I：

10.1101/gad.215426.113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.

引用

页码：853 / 858

页数：6

共 40 条

[1] Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context [J].

Alekeyenko, Artyom A. ;

Ho, Joshua W. K. ;

Peng, Shouyong ;

Gelbart, Marnie ;

Tolstorukov, Michael Y. ;

Plachetka, Annette ;

Kharchenko, Peter V. ;

Jung, Youngsook L. ;

Gorchakov, Andrey A. ;

Larschan, Erica ;

Gu, Tingting ;

Minoda, Aki ;

Riddle, Nicole C. ;

Schwartz, Yuri B. ;

Elgin, Sarah C. R. ;

Karpen, Gary H. ;

Pirrotta, Vincenzo ;

Kuroda, Mitzi I. ;

Park, Peter J. .

PLOS GENETICS, 2012, 8 (04) :351-363

[2] High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome [J].

Alekseyenko, AA ;

Larschan, E ;

Lai, WR ;

Park, PJ ;

Kuroda, MI .

GENES & DEVELOPMENT, 2006, 20 (07) :848-857

[3] A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome [J].

Alekseyenko, Artyom A. ;

Peng, Shouyong ;

Larschan, Erica ;

Gorchakov, Andrey A. ;

Lee, Ok-Kyung ;

Kharchenko, Peter ;

McGrath, Sean D. ;

Wang, Charlotte I. ;

Mardis, Elaine R. ;

Park, Peter J. ;

Kuroda, Mitzi I. .

CELL, 2008, 134 (04) :599-609

[4] Reduced adaptation of a non-recombining neo-Y chromosome [J].

Bachtrog, D ;

Charlesworth, B .

NATURE, 2002, 416 (6878) :323-326

[5] Positive Selection at the Binding Sites of the Male-Specific Lethal Complex Involved in Dosage Compensation in Drosophila [J].

Bachtrog, Doris .

GENETICS, 2008, 180 (02) :1123-1129

[6] Genomic degradation of a young Y chromosome in Drosophila miranda [J].

Bachtrog, Doris ;

Hom, Emily ;

Wong, Karen M. ;

Maside, Xulio ;

de Jong, Pieter .

GENOME BIOLOGY, 2008, 9 (02)

[7] MEME SUITE: tools for motif discovery and searching [J].

Bailey, Timothy L. ;

Boden, Mikael ;

Buske, Fabian A. ;

Frith, Martin ;

Grant, Charles E. ;

Clementi, Luca ;

Ren, Jingyuan ;

Li, Wilfred W. ;

Noble, William S. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :W202-W208

[8] Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster [J].

Bell, Oliver ;

Conrad, Thomas ;

Kind, Jop ;

Wirbelauer, Christiane ;

Akhtar, Asifa ;

Schuebeler, Dirk .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (10) :3401-3409

[9] Scaffolding pre-assembled contigs using SSPACE [J].

Boetzer, Marten ;

Henkel, Christiaan V. ;

Jansen, Hans J. ;

Butler, Derek ;

Pirovano, Walter .

BIOINFORMATICS, 2011, 27 (04) :578-579

[10]

Bone JR, 1996, GENETICS, V144, P705

← 1 2 3 4 →