The solution to a deep stereochemical conundrum: Studies toward the tetrahydroisoquinoline alkaloids

被引：23

作者：

Chan, C ^{[1
]}

Zheng, SP ^{[1
]}

Zhou, BS ^{[1
]}

Guo, J ^{[1
]}

Heid, RM ^{[1
]}

Wright, BJD ^{[1
]}

Danishefsky, S ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 11期

关键词：

antitumor agents; asymmetric synthesis; Mannich cyclization; natural products; total synthesis;

D O I：

10.1002/anie.200503982

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Facile construction of subunits 1 and 2 allowed the rapid assembly of the pentacyclic ring system 3 of the cytotoxic tetrahydroisoquinoline alkaloids. A surprising participation reaction was discovered, which necessitated revision of the stereochemical assignments of key intermediates en route to 3. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1749 / 1754

页数：6