Key enzymes of prostaglandin biosynthesis and metabolism. Coordinate regulation of expression by cytokines in gestational tissues: A review

被引：44

作者：

Hansen, WR ^{[1
]}

Keelan, JA ^{[1
]}

Skinner, SJM ^{[1
]}

Mitchell, MD ^{[1
]}

机构：

[1] Univ Auckland, Sch Med, Dept Pharmacol & Clin Pharmacol, Auckland, New Zealand

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1999年 / 57卷 / 04期

关键词：

cytokines; prostaglandins; gestational tissue;

D O I：

10.1016/S0090-6980(99)00008-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preterm labor is frequently associated with ascending intrauterine infection, accompanied by leukocytes infiltration and enhanced local production of cytokines and other inflammatory mediators. The resulting amplification of the inflammatory response, and of prostanoid production in particular, is postulated to be a principal mechanism of infection-driven preterm labor. In this review the effects of pro- and anti-inflammatory cytokines are discussed with respect to the expression of enzymes involved in three key steps of prostanoid biosynthesis and metabolism: liberation of arachidonic acid (AA), conversion of AA to bioactive prostanoids, and prostanoid catabolism. We suggest that by exerting coordinate actions on all three key steps, through multiple molecular mechanisms, inflammatory cytokines acutely up-regulate prostanoid production in intrauterine tissues. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：243 / 257

页数：15

共 122 条

[1] ACTIONS OF INTERLEUKIN-4 ON PROSTAGLANDIN BIOSYNTHESIS AT THE CHORION-DECIDUAL INTERFACE [J].

ADAMSON, S ;

EDWIN, SS ;

LAMARCHE, S ;

MITCHELL, MD .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (06) :1442-1447

[2] ACTIONS OF INTERLEUKIN-4 ON PROSTAGLANDIN BIOSYNTHESIS BY HUMAN AMNION CELLS [J].

ADAMSON, S ;

EDWIN, SS ;

LAMARCHE, S ;

MITCHELL, MD .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1994, 50 (03) :133-135

[3] TYPE-II PHOSPHOLIPASE-A(2) IN HUMAN GESTATIONAL TISSUES - EXTRACTABLE IMMUNO- AND ENZYMATIC-ACTIVITY IN FETAL MEMBRANES [J].

AITKEN, MA ;

FARRUGIA, W ;

WONG, MH ;

SCOTT, KF ;

BRENNECKE, SP ;

RICE, GE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1170 (03) :314-320

[4] INTERLEUKIN-1-BETA REGULATES THE INDUCIBLE CYCLOOXYGENASE IN AMNION-DERIVED WISH CELLS [J].

ALBERT, TJ ;

SU, HC ;

ZIMMERMAN, PD ;

IAMS, JD ;

KNISS, DA .

PROSTAGLANDINS, 1994, 48 (06) :401-416

[5] BIOLOGICAL ACTIVITIES OF 3 METABOLITES OF PROSTAGLANDIN E1 [J].

ANGGARD, E .

ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 66 (04) :509-&

[6] Lipopolysaccharide enhances the transcription of prostaglandin H synthase-2 gene in primary human trophoblasts [J].

Anteby, EY ;

Johnson, RD ;

Huang, XH ;

Dryden, DK ;

Nelson, DM ;

Sadovsky, Y .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1998, 178 (03) :469-473

[7] Transcriptional regulation of prostaglandin-H synthase-2 gene in human trophoblasts [J].

Anteby, EY ;

Johnson, RD ;

Huang, XH ;

Nelson, DM ;

Sadovsky, Y .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (07) :2289-2293

[8]

ATSUMI G, 1997, BIOCHIM BIOPHYS ACTA, V1349, P1043

[9] Interleukin-1 beta intra-amniotic infusion induces tumor necrosis Factor-alpha, prostaglandin production, and preterm contractions in pregnant rhesus monkeys [J].

Baggia, S ;

Gravett, MG ;

Witkin, SS ;

Haluska, GJ ;

Novy, MJ .

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 1996, 3 (03) :121-126

[10] Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 [J].

Balsinde, J ;

Balboa, MA ;

Dennis, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :7951-7956

← 1 2 3 4 5 6 7 8 9 10 →