The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration

被引:4
作者
Elghazali, M
Wasfi, IA
Al Katheeri, NA
Hadi, AAA
Hussein, MM
机构
[1] Forens Sci Lab, Camelracing Lab, Abu Dhabi, U Arab Emirates
[2] Camel Res Ctr, Abu Dhabi, U Arab Emirates
关键词
D O I
10.1046/j.1365-2885.2002.00383.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmacokinetics of etamiphylline were determined after an intramuscular (i.m.) dose of 3.5 mg/kg body weight in six healthy camels. Furthermore, the metabolites and drug detection time were evaluated. The data obtained median and (range) were as follows: the terminal elimination half-life (t(1/2beta), h) was 3.04 (2.03-3.62); apparent total body clearance (Cl/F, L/h/kg) was 1.27 (0.74-2.99); the apparent volume of distribution at steady state (V(SS)/F, L/kg) was 4.94 (3.57-12.54); and renal clearance (Cl(r) L/h/kg) determined in two camels was 0.005 and 0.004, respectively. The detection time of etamiphylline in urine after an i.m. dose of 3.5 mg/kg body weight ranged between 12 and 13 days. Three etamiphylline metabolites were tentatively identified in camels urine: The first one desethyletamiphylline was the main metabolite and resulted from N-deethylation of etamiphylline had a molecular weight of 251, and was detected in urine for about 13-14 days. Theophylline (molecular weight 180) was the second metabolite and resulted from ring N-dealkylation of etamiphylline. It was present in small amounts and was detected for about 5 h after drug administration in urine. The third metabolite, possibly resulted from demethylation of etamiphylline, had a molecular weight of m/z 265, and was present in small amounts and was detected in urine for about 5 h after drug administration.
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页码:43 / 48
页数:6
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