Positive selection can create false hotspots of recombination

被引：43

作者：

Reed, FA ^{[1
]}

Tishkoff, SA ^{[1
]}

机构：

[1] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

来源：

GENETICS | 2006年 / 172卷 / 03期

关键词：

D O I：

10.1534/genetics.105.052183

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

引用

页码：2011 / 2014

页数：4

共 42 条

[1] Population history and natural selection shape patterns of genetic variation in 132 genes [J].

Akey, JM ;

Eberle, MA ;

Rieder, MJ ;

Carlson, CS ;

Shriver, MD ;

Nickerson, DA ;

Kruglyak, L .

PLOS BIOLOGY, 2004, 2 (10) :1591-1599

[2] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[3] Adaptive hitchhiking effects on genome variability [J].

Andolfatto, P .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (06) :635-641

[4] Genome-wide variation in the human and fruitfly: a comparison [J].

Aquadro, CF ;

DuMont, VB ;

Reed, FA .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (06) :627-634

[5] Hot and cold spots of recombination in the human genome: The reason we should find them and how this can be achieved [J].

Arnheim, N ;

Calabrese, P ;

Nordborg, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (01) :5-16

[6] Signatures of natural selection in the human genome [J].

Bamshad, M ;

Wooding, SP .

NATURE REVIEWS GENETICS, 2003, 4 (02) :99-111A

[7]

CHAKRAVARTI A, 1984, AM J HUM GENET, V63, P861

[8] Evidence for substantial fine-scale variation in recombination rates across the human genome [J].

Crawford, DC ;

Bhangale, T ;

Li, N ;

Hellenthal, G ;

Rieder, MJ ;

Nickerson, DA ;

Stephens, M .

NATURE GENETICS, 2004, 36 (07) :700-706

[9]

CULLEN M, 1995, AM J HUM GENET, V56, P1350

[10] Distribution of meiotic recombination sites [J].

de Massy, B .

TRENDS IN GENETICS, 2003, 19 (09) :514-522

← 1 2 3 4 5 →