Positive selection can create false hotspots of recombination

被引：43

作者：

Reed, FA ^{[1
]}

Tishkoff, SA ^{[1
]}

机构：

[1] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

来源：

GENETICS | 2006年 / 172卷 / 03期

关键词：

D O I：

10.1534/genetics.105.052183

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

引用

页码：2011 / 2014

页数：4

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