Nickel (0)/dihydroimidazol-2-ylidene complex catalyzed coupling of aryl chlorides and amines

被引：202

作者：

Desmarets, C ^{[1
]}

Schneider, R ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, UMR 7565, Fac Sci, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 09期

关键词：

D O I：

10.1021/jo016352l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and simple nickel-catalyzed coupling of aryl chlorides and amines is reported. The scope and limitations of the coupling process using Ni(0), 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene, and NaO-t-Bu as base were investigated. Secondary cyclic and acyclic amines and anilines provided the arylamine coupling products in good to excellent yields. Compared to palladium-catalyzed aminations, this procedure offers an alternative route to N-substituted anilines starting from readily available aryl chlorides.

引用

页码：3029 / 3036

页数：8

共 83 条

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