Presence of an acidic glycoprotein in the serum of arthritic rats: Modulation by capsaicin and curcumin

Levels of various serum proteins were found to change in adjuvant induced arthritis. Increased levels of a glycoprotein with an apparent molecular weight of 72 kDa (Gp A(72)) were observed in the sera of arthritic rats. Gp A(72) is an acidic glycoprotein with a pi of 5.1. Gp A(72) also showed antitryptic activity. The appearance of Gp A(72) in the serum preceded the onset of paw inflammation in arthritic rats and persisted in the chronic phase. Oral administration of the antiinflammatory spice principles-capsaicin (from red pepper) and curcumin (from turmeric) lowered the levels of Gp A(72) by 88 and 73% respectively with concomitant lowering of paw inflammation in arthritic rats.