Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus)

被引：36

作者：

Umemura, T

Tanaka, Y

Kiyosawa, K

Alter, HJ

Shih, JWK ^{[1
]}

机构：

[1] NIH, Warren G Magnuson Clin Ctr, Dept Transfus Med, Bethesda, MD 20892 USA

[2] Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan

来源：

FEBS LETTERS | 2002年 / 510卷 / 03期

关键词：

evolutionary rate; hypervariable regions; phylogenetic analysis; positive selection; TT virus; Circoviridae;

D O I：

10.1016/S0014-5793(01)03258-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the evolution of SEN virus (SEN-V), serial sequences of chronically SEN-V-infected patients were analyzed. In the hypervariable regions, non-synonymous substitutions significantly predominated. This could be attributed to positive selection in evading immune surveillance of the hosts and to establish a persistent infection. On the basis of the sequences in the two open reading frames of SEN-V DNA, the rate of synonymous substitutions was 7.32X10(-4) per site per year. Since this rate is close to RNA viruses and higher than other DNA viruses, the SEN-V might be replicated by machinery with poor or no proofreading function. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：171 / 174

页数：4

相关论文

共 31 条

[11] PSEUDOGENES AS A PARADIGM OF NEUTRAL EVOLUTION [J].

LI, WH ;

GOJOBORI, T ;

NEI, M .

NATURE, 1981, 292 (5820) :237-239

[12] Long-term evolution of the hypervariable region of hepatitis C virus in a common-source-infected cohort [J].

McAllister, J ;

Casino, C ;

Davidson, F ;

Power, J ;

Lawlor, E ;

Yap, PL ;

Simmonds, P ;

Smith, DB .

JOURNAL OF VIROLOGY, 1998, 72 (06) :4893-4905

[13] TEMPORAL FLUCTUATIONS IN HIV QUASISPECIES INVIVO ARE NOT REFLECTED BY SEQUENTIAL HIV ISOLATIONS [J].

MEYERHANS, A ;

CHEYNIER, R ;

ALBERT, J ;

SETH, M ;

KWOK, S ;

SNINSKY, J ;

MORFELDTMANSON, L ;

ASJO, B ;

WAINHOBSON, S .

CELL, 1989, 58 (05) :901-910

[14]

NEI M, 1986, MOL BIOL EVOL, V3, P418

[15]

Niewiesk S, 1996, J MOL EVOL, V42, P452, DOI 10.1007/BF02498639

[16] Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection [J].

Nishizawa, T ;

Okamoto, H ;

Tsuda, F ;

Aikawa, T ;

Sugai, Y ;

Konishi, K ;

Akahane, Y ;

Ukita, M ;

Tanaka, T ;

Miyakawa, Y ;

Mayumi, M .

JOURNAL OF VIROLOGY, 1999, 73 (11) :9604-9608

[17] A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology [J].

Nishizawa, T ;

Okamoto, H ;

Konishi, K ;

Yoshizawa, H ;

Miyakawa, Y ;

Mayumi, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (01) :92-97

[18] Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions [J].

Okamoto, H ;

Takahashi, M ;

Nishizawa, T ;

Ukita, M ;

Fukuda, M ;

Tsuda, F ;

Miyakawa, Y ;

Mayumi, M .

VIROLOGY, 1999, 259 (02) :428-436

[19] HOST-INDEPENDENT EVOLUTION AND A GENETIC CLASSIFICATION OF THE HEPADNAVIRUS FAMILY BASED ON NUCLEOTIDE-SEQUENCES [J].

ORITO, E ;

MIZOKAMI, M ;

INA, Y ;

MORIYAMA, EN ;

KAMESHIMA, N ;

YAMAMOTO, M ;

GOJOBORI, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :7059-7062

[20]

Primi DG, 2000, Patent No. [WO 00/28039, 0028039]

← 1 2 3 4 →