Silk fibroin membrane used for guided bone tissue regeneration

被引：82

作者：

Cai, Yurong ^{[1
]}

Guo, Junmao ^{[1
]}

Chen, Cen ^{[2
]}

Yao, Chenxue ^{[2
]}

Chung, Sung-Min ^{[3
]}

Yao, Juming ^{[1
]}

Lee, In-Seop ^{[4
]}

Kong, Xiangdong ^{[2
]}

机构：

[1] Zhejiang Sci Tech Univ, Coll Mat & Text, Natl Engn Lab Text Fiber Mat & Proc Technol Zheji, Minist Educ,Key Lab Adv Text Mat & Mfg Technol, Hangzhou 310018, Zhejiang, Peoples R China

[2] Zhejiang Sci Tech Univ, Coll Life Sci, Bio X Ctr, Hangzhou 310018, Zhejiang, Peoples R China

[3] Sung Min Chung Genoss Co Ltd, Suwon 443270, South Korea

[4] Yonsei Univ, Inst Nat Sci, 134 Shinchon Dong, Seoul 120749, South Korea

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 70卷

基金：

中国国家自然科学基金;

关键词：

Guided bone regeneration; Silk fibroin; Degradable; Osteoconductive; Mechanical properties; IN-VITRO DEGRADATION; CALCIUM-PHOSPHATE; CROSS-LINKING; BIOMATERIAL; FABRICATION; SPONGES;

D O I：

10.1016/j.msec.2016.08.070

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

With the aim to develop a novel membrane with an appropriate mechanical property and degradation rate for guided bone tissue regeneration, lyophilized and densified silk fibroin membrane was fabricated and its mechanical behavior as well as biodegradation property were investigated. The osteoconductive potency of the silk fibroin membranes were evaluated in a defect rabbit calvarial model. Silk fibroin membrane showed the modulated biodegradable and mechanical properties via ethanol treatment with different concentration. The membrane could prevent soft tissue invasion from normal tissue healing, and the amounts of new bone and defect closure with silk fibroin membrane were similar to those of commercially available collagen membrane. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：148 / 154

页数：7

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