Quantification of citrate concentration in the prostate by proton magnetic resonance spectroscopy: Zonal and age-related differences

被引:53
作者
Lowry, M [1 ]
Liney, GP [1 ]
Turnbull, LW [1 ]
Manton, DJ [1 ]
Blackband, SJ [1 ]
Horsman, A [1 ]
机构
[1] HULL ROYAL INFIRM,DEPT MED PHYS,KINGSTON HULL,N HUMBERSIDE,ENGLAND
关键词
prostate; citrate; magnetic resonance spectroscopy; quantification;
D O I
10.1002/mrm.1910360305
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A commercial phased-array multicoil was used to acquire water-suppressed localized proton spectra of the two major anatomical regions of the prostate. The signal-to-noise ratio and spectral resolution allowed identification of peaks from choline and creatine, as well as a major peak from citrate, Quantification of the citrate peak using experimentally determined relaxation parameters with tissue water as an internal concentration reference revealed a marked variability between different volunteers. Nevertheless, in each case, the citrate concentration was up to fourfold greater in the peripheral zone than in the central gland, Furthermore, the difference in citrate concentration between these two regions was positively correlated with the subjects age, The results indicate a consistent difference in cellular function between the major anatomical regions within the prostate and may have important consequences for the application of magnetic resonance spectroscopy to the diagnosis of prostatic pathology.
引用
收藏
页码:352 / 358
页数:7
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