Alternative splicing: decoding an expansive regulatory layer

被引：128

作者：

Irimia, Manuel ^{[1
]}

Blencowe, Benjamin J. ^{[1
,2
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Donnelly Ctr, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 03期

基金：

加拿大健康研究院;

关键词：

RNA-BINDING PROTEIN; STEM-CELL PLURIPOTENCY; GENOME-WIDE ANALYSIS; REVEALS; TRANSCRIPTOME; EVOLUTION; INSIGHTS; METHYLATION; LONG; IDENTIFICATION;

D O I：

10.1016/j.ceb.2012.03.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative splicing (AS) is the process by which splice sites in precursor (pre)-mRNA are differentially selected to produce multiple mRNA and protein isoforms. During the past few years the application of genome-wide profiling technologies coupled with bioinformatic approaches has transformed our understanding of AS complexity and regulation. These studies are further driving research directed at elucidating the functions of networks of regulated AS events in the context of normal physiology and disease. Major strides have also been made in understanding how AS is functionally integrated with- and coupled to- gene regulation at the level of chromatin and transcription. Particularly intriguing is the discovery of new AS 'switches' that control transcriptional networks required for animal development and behavior.

引用

页码：323 / 332

页数：10

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