Long-Term Effects of Exposure to Disease-Modifying Drugs in the Offspring of Mothers with Multiple Sclerosis: A Retrospective Chart Review

被引：17

作者：

Fragoso, Yara D. ^{[1
]}

Adoni, Tarso ^{[2
]}

Alves-Leon, Soniza V. ^{[3
]}

Azambuja, Nerio D., Jr. ^{[4
]}

Barreira, Amilton A. ^{[5
]}

Brooks, Joseph B. B. ^{[1
]}

Carneiro, Denise S. D. ^{[6
]}

Carvalho, Margarete J. ^{[7
]}

Claudino, Rinaldo ^{[8
]}

Comini-Frota, Elizabeth R. ^{[9
]}

Domingues, Renan B. ^{[10
]}

Finkelzstejn, Alessandro ^{[11
]}

Gama, Paulo D. ^{[12
]}

Giacomo, Maria C. B. ^{[13
]}

Gomes, Sidney ^{[14
,15
]}

Goncalves, Marcus V. M. ^{[16
]}

Grzesiuk, Anderson K. ^{[17
]}

Kaimen-Maciel, Damacio R. ^{[18
]}

Mendes, Maria F. ^{[19
]}

Morales, Nivea M. O. ^{[20
]}

Morales, Rogerio R. ^{[20
]}

Muniz, Andre ^{[21
]}

Papais-Alvarenga, Regina M. ^{[22
]}

Parolin, Monica K. F. ^{[23
]}

Ribeiro, Sonia B. F. ^{[24
]}

Ruocco, Heloisa H. ^{[25
]}

Siquineli, Fabio ^{[26
]}

Tosta, Elza D. ^{[27
]}

机构：

[1] Univ Metropolitana Santos UNIMES, Sch Med, Dept Neurol, BR-11015470 Santos, SP, Brazil

[2] Sirio Libanes Hosp, Dept Neurol, Sao Paulo, Brazil

[3] Univ Fed Rio de Janeiro, Dept Neurol, Rio De Janeiro, Brazil

[4] Neurol & Neurosurg Passo Fundo, Passo Fundo, RS, Brazil

[5] Univ Sao Paulo, Dept Neurol, BR-14049 Ribeirao Preto, Brazil

[6] Univ Fed Goias, Dept Neurol, Goiania, Go, Brazil

[7] Fundacao ABC, Sch Med, Dept Neurol, Santo Andre, SP, Brazil

[8] Univ Fed Santa Catarina, Dept Neurol, Florianopolis, SC, Brazil

[9] Univ Fed Minas Gerais, Dept Neurol, Belo Horizonte, MG, Brazil

[10] Santa Casa Vitoria, Sch Hlth Sci, Dept Neurol, Vitoria, Spain

[11] Hosp Clin Porto Alegre, Dept Neurol, Porto Alegre, RS, Brazil

[12] Pontificia Univ Catolica, Dept Neurol, Sorocaba, SP, Brazil

[13] Neurol Clin, Sao Paulo, Brazil

[14] Beneficencia Portuguesa Hosp, Dept Neurol, Sao Paulo, Brazil

[15] Paulistano Hosp, Sao Paulo, Brazil

[16] Univ Regiao Joinville, Dept Neurol, Joinville, SC, Brazil

[17] Rehabil Ctr Dom Aquino Correa, Cuiaba, MT, Brazil

[18] Univ Estadual Londrina, Dept Neurol, Londrina, PR, Brazil

[19] Santa Casa Sao Paulo, Dept Neurol, Sao Paulo, Brazil

[20] Univ Fed Uberlandia, Dept Neurol, BR-38400 Uberlandia, MG, Brazil

[21] Sao Rafael Hosp, Dept Neurol, Salvador, BA, Brazil

[22] Univ Fed Rio de Janeiro, Dept Neurol, Rio De Janeiro, Brazil

[23] Neurol Clin, Curitiba, Parana, Brazil

[24] Univ Fed Triangulo Mineiro, Dept Neurol, Uberaba, MG, Brazil

[25] MS Ctr Jundiai, Jundiai, SP, Brazil

[26] Univ Reg Blumenau, Dept Neurol, Blumenau, SC, Brazil

[27] Hosp Base Dist Fed, Dept Neurol, Brasilia, DF, Brazil

来源：

CNS DRUGS | 2013年 / 27卷 / 11期

关键词：

PREGNANCY REGISTRIES; GLATIRAMER ACETATE; WOMEN;

D O I：

10.1007/s40263-013-0113-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) mainly affects women of fertile age. To date, the only recommendation for women with MS intending to become pregnant is to stop all treatment. This recommendation reflects the concerns about the effects of disease-modifying drugs (DMDs) on the offspring. The objective of the present study was to assess the potential long-term effects of maternal exposure to DMDs on the offspring. This was a retrospective study revising medical data on the offspring of women with MS. These women now have children aged at least 1 year and include a group of patients that were not exposed to any DMDs for at least 3 months prior to pregnancy and during the whole gestation (control group). Another group of patients had at least 2 weeks of exposure to DMDs, mainly to interferon beta or glatiramer acetate The women with MS participating in this study have children currently aged, on average, 6.6 years (range 1-39 years). There was no pattern of drug-related adverse events or complications in the children whose mothers were exposed to DMDs. No specific long-term adverse events were observed in the offspring of women with MS who were exposed to drugs during pregnancy. The profile of relevant diagnoses in their children was similar to that of children whose mothers had not been exposed to DMDs. The present retrospective study did not show a specific profile of long-term deleterious drug effects on children born from mothers who were exposed to drugs for MS treatment.

引用

页码：955 / 961

页数：7

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