The Brazilian database on pregnancy in multiple sclerosis

被引：51

作者：

Finkelsztejn, A. ^{[3
]}

Fragoso, Y. D. ^{[1
,2
]}

Ferreira, M. L. B. ^{[4
]}

Lana-Peixoto, M. A. ^{[5
,6
]}

Alves-Leon, S. V. ^{[7
,8
]}

Gomes, S. ^{[9
,10
]}

Damasceno, B. P. ^{[11
]}

Mendes, M. F. ^{[12
]}

Salgado, P. R. ^{[13
]}

Correa, E. C. ^{[14
]}

Comini-Frota, E. R. ^{[6
]}

Diniz, D. S. ^{[15
]}

Gama, P. D. ^{[16
]}

Kaimen-Maciel, D. R. ^{[17
,18
]}

Morales, R. R. ^{[19
]}

Arruda, W. O. ^{[20
]}

Grzesiuk, A. K. ^{[21
,22
]}

Khouri, J. M. N. ^{[23
,24
]}

Lopes, J. S.

Rocha, C. F. ^{[5
,6
]}

Domingues, R. ^{[25
]}

Goncalves, M. V. M.

Lorenti, M. A. ^{[26
]}

Parolin, M. K. F. ^{[27
]}

Siquineli, F.

Tosta, E. D. ^{[28
]}

Brooks, J. B. B. ^{[2
]}

Gallina, A. S.

Melges, L. D. M. ^{[29
]}

Ruocco, H. H. ^{[30
]}

机构：

[1] Univ Metropolitana Santos, Dept Neurol, Sch Med, BR-11015470 Santos, SP, Brazil

[2] DRS IV, Santos, SP, Brazil

[3] HC Porto Alegre, Porto Alegre, RS, Brazil

[4] CRAPPDD HR, Recife, PE, Brazil

[5] CIEM, Belo Horizonte, MG, Brazil

[6] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

[7] UFRJ, Rio De Janeiro, Brazil

[8] HUCFF, Rio De Janeiro, Brazil

[9] HBP, Sao Paulo, Brazil

[10] H Paulistano, Sao Paulo, Brazil

[11] Univ Estadual Campinas, Campinas, SP, Brazil

[12] FMSCSP, Sao Paulo, Brazil

[13] Univ Fed Mato Grosso do Sul, Campo Grande, MS, Brazil

[14] ICB, Brasilia, DF, Brazil

[15] Univ Fed Goias, Goiania, GO, Brazil

[16] PUC, Sorocaba, SP, Brazil

[17] CCS, Londrina, PR, Brazil

[18] Univ Estadual Londrina, Londrina, PR, Brazil

[19] Univ Fed Uberlandia, Uberlandia, MG, Brazil

[20] UFP, Curitiba, PR, Brazil

[21] INC, Cuiaba, MT, Brazil

[22] HSR, Cuiaba, MT, Brazil

[23] SCC, Curitiba, PR, Brazil

[24] UP, Curitiba, PR, Brazil

[25] EMESCAM, Vitoria, ES, Brazil

[26] HSPE, Sao Paulo, Brazil

[27] SESA, Curitiba, PR, Brazil

[28] HBDF, Brasilia, DF, Brazil

[29] FAMEMA, Marilia, SP, Brazil

[30] HUJ, Jundiai, SP, Brazil

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2011年 / 113卷 / 04期

关键词：

Multiple sclerosis; Pregnancy; Beta interferon; Glatiramer acetate; POPULATION; DELIVERY; OUTCOMES; WOMEN; RISK;

D O I：

10.1016/j.clineuro.2010.11.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: To report the results from the Brazilian database on multiple sclerosis (MS) and pregnancy. Methods: Retrospective data from MS patients who became pregnant at any time of their disease were sent to a Brazilian database, using a specific file for this purpose. Results: Data on 128 women (142 pregnancies) from 30 neurologists working in 21 cities in Brazil were collected. Patients' average age at pregnancy was 29.8 years (range 16-42). EDSS at start of pregnancy was 1.5 +/- 1.4; and the relapse rate in the year preceding pregnancy was 1.2 +/- 1.5. Exposure to medication at any time during pregnancy was high (69.7%): 48.6% to interferon beta; 14.1% to glatiramer acetate; and 7% to other immunomodulatory and immunosuppressive drugs. There was a significant decrease in relapse rate during pregnancy. The prevalence of complications was relatively low, with 4.9% of obstetric and 1.4% neonatal unfavorable outcomes. Conclusions: Our patients had low degrees of disability, short histories of disease, high drug exposure, and relatively high relapse rate in the year previous to pregnancy. Obstetric and neonatal outcomes were successful in over 90% of our patients. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：277 / 280

页数：4

共 13 条

[1] Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study [J].

Chen, Y. H. ;

Lin, H. L. ;

Lin, H. C. .

MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (05) :606-612

[2]

Confravreux C, 1998, NEW ENGL J MED, V339, P283

[3] Pregnancy, delivery and birth outcome in different stages of maternal multiple sclerosis [J].

Dahl, Julie ;

Myhr, Kjell-Morten ;

Daltveit, Anne Kjersti ;

Gilhus, Nils Erik .

JOURNAL OF NEUROLOGY, 2008, 255 (05) :623-627

[4] Pregnancy in multiple sclerosis patients treated with immunomodulators prior to or during part of the pregnancy:: a descriptive study in the Spanish population [J].

De las Heras, V. ;

De Andres, C. ;

Tellez, N. ;

Tintore, M. .

MULTIPLE SCLEROSIS JOURNAL, 2007, 13 (08) :981-984

[5] PREGNANCY AND MULTIPLE SCLEROSIS The initial results from a Brazilian database [J].

Fragoso, Yara Dadalti ;

Finkelsztejn, Alessandro ;

Comini-Frota, Elizabeth Regina ;

da Gama, Paulo Diniz ;

Grzesiuk, Ansderson Kuntz ;

Netto Khouri, Jussara Mathias ;

Alves-Leon, Soniza Vieira ;

Morales, Rogerio de Rizo ;

Lana-Peixoto, Marco Aurelio ;

da Rocha, Cristiane Franklin .

ARQUIVOS DE NEURO-PSIQUIATRIA, 2009, 67 (3A) :657-660

[6] Parity and secondary progression in multiple sclerosis [J].

Koch, M. ;

Uyttenboogaart, M. ;

Heersema, D. ;

Steen, C. ;

De Keyser, J. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (06) :676-678

[7]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[8] Exclusive Breastfeeding and the Risk of Postpartum Relapses in Women With Multiple Sclerosis [J].

Langer-Gould, Annette ;

Huang, Stella M. ;

Gupta, Rohit ;

Leimpeter, Amethyst D. ;

Greenwood, Eleni ;

Albers, Kathleen B. ;

Van den Eeden, Stephen K. ;

Nelson, Lorene M. .

ARCHIVES OF NEUROLOGY, 2009, 66 (08) :958-963

[9] Epidemiological characteristics of pregnancy, delivery, and birth outcome in women with multiple sclerosis in Argentina (EMEMAR study) [J].

Liguori, N. Fernandez ;

Klajn, D. ;

Acion, L. ;

Caceres, F. ;

Calle, A. ;

Carra, A. ;

Cristiano, E. ;

Deri, N. ;

Garcea, O. ;

Jaureguiberry, A. ;

Onaha, P. ;

Patrucco, L. ;

Riccio, P. ;

Rotta Escalante, R. ;

Saladino, M. L. ;

Sinay, V. ;

Tarulla, A. ;

Villa, A. .

MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (05) :555-562

[10] Relapses in multiple sclerosis Important or not? [J].

Marrie, Ruth Ann ;

Cutter, Gary .

NEUROLOGY, 2009, 73 (20) :1612-1613

← 1 2 →