Apoptosis detection using magnetic resonance imaging and spectroscopy

被引：31

作者：

Kettunen, MI ^{[1
]}

Brindle, KM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | 2005年 / 47卷 / 3-4期

基金：

英国生物技术与生命科学研究理事会;

关键词：

apoptosis; magnetic resonance imaging; magnetic resonance spectroscopy; contrast agents; molecular imaging;

D O I：

10.1016/j.pnmrs.2005.08.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Apoptosis detection using magnetic resonance imaging and spectroscopy is discussed. The applicability for detecting apoptosis in a clinical setting is also discussed. The potential of the methods is compared with other methods such as radionuclide imaging. The process of apoptosis is mediated by increasingly well-defined signaling pathways in the cell. MR spectroscopy is a valuable and now indeed venerable tool for the non-invasive investigation of metabolism in intact cells and tissues.

引用

页码：175 / 185

页数：11

共 137 条

[41]

Griffin JL, 2003, CANCER RES, V63, P3195

[42]

Gröhn OHJ, 2003, CANCER RES, V63, P7571

[43]

Gupta RK, 1999, MAGNET RESON MED, V41, P2, DOI 10.1002/(SICI)1522-2594(199901)41:1<2::AID-MRM2>3.0.CO

[44]

2-Y

[45] Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma [J].

Gupta, RK ;

Cloughesy, TF ;

Sinha, U ;

Garakian, J ;

Lazareff, J ;

Rubino, G ;

Rubino, L ;

Becker, DP ;

Vinters, HV ;

Alger, JR .

JOURNAL OF NEURO-ONCOLOGY, 2000, 50 (03) :215-226

[46] In vivo imaging of radiation-induced apoptosis in follicular lymphoma patients [J].

Haas, RLM ;

de Jong, D ;

Olmos, RAV ;

Hoefnagel, CA ;

van Den Heuvel, I ;

Zerp, SF ;

Bartelink, H ;

Verheij, M .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (03) :782-787

[47] 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma:: Implications for the in vivo detection of apoptosis [J].

Hakumäki, JM ;

Poptani, H ;

Sandmair, AM ;

Ylä-Herttuala, S ;

Kauppinen, RA .

NATURE MEDICINE, 1999, 5 (11) :1323-1327

[48]

Hakumäki JM, 1998, CANCER RES, V58, P3791

[49] Early gene therapy-induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame [J].

Hakumäki, JM ;

Gröhn, OHJ ;

Tyynelä, K ;

Valonen, P ;

Ylä-Herttuala, S ;

Kauppinen, RA .

CANCER GENE THERAPY, 2002, 9 (04) :338-345

[50] 1H NMR visible lipids in the life and death of cells [J].

Hakumäki, JM ;

Kauppinen, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (08) :357-362

← 1 2 3 4 5 6 7 8 9 10 →