Beyond licensing and disarming: A quantitative view on NK-cell education

被引：43

作者：

Brodin, Petter ^{[1
]}

Hoglund, Petter ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 11期

基金：

瑞典研究理事会;

关键词：

Education; NK-cell; Quantitative; Reversibility; Tolerance;

D O I：

10.1002/eji.200838760

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this article, we will move beyond the current controversy of different models for NK-cell education and instead discuss the properties characterizing MHC class I-guided functional development of NK cells. We will argue that this development, which represents the endpoint of NK-cell education, is a quantitative and dynamic, and perhaps even reversible, process.

引用

页码：2934 / 2937

页数：4

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