Cellular uptake of PNA -: Terpyridine conjugates and its enhancement by Zn2+ ions

被引：31

作者：

Fuessl, Andreas

Schleifenbaum, Andreas

Goeritz, Mareike

Riddell, Andrew

Schultz, Carsten

Kraemer, Roland

机构：

[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany

[2] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 18期

关键词：

D O I：

10.1021/ja0571139

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+. Copyright © 2006 American Chemical Society.

引用

收藏

页码：5986 / 5987

页数：2

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