ATRP under Biologically Relevant Conditions: Grafting from a Protein
被引:222
作者:
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Averick, Saadyah
[1
]
Simakova, Antonina
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
Simakova, Antonina
[1
]
Park, Sangwoo
论文数: 0引用数: 0
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Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
Park, Sangwoo
[1
]
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Konkolewicz, Dominik
[1
]
Magenau, Andrew J. D.
论文数: 0引用数: 0
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Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
Magenau, Andrew J. D.
[1
]
Mehl, Ryan A.
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Franklin & Marshall Coll, Dept Chem, Lancaster, PA 17604 USACarnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
Mehl, Ryan A.
[2
]
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Matyjaszewski, Krzysztof
[1
]
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[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA
[2] Franklin & Marshall Coll, Dept Chem, Lancaster, PA 17604 USA
来源:
ACS MACRO LETTERS
|
2012年
/
1卷
/
01期
关键词:
TRANSFER RADICAL POLYMERIZATION;
POLYMERS;
AMPHIPHILES;
PEGYLATION;
INITIATOR;
FEATURES;
LIGAND;
GROWTH;
D O I:
10.1021/mz200020c
中图分类号:
O63 [高分子化学(高聚物)];
学科分类号:
070305 ;
080501 ;
081704 ;
摘要:
Atom transfer radical polymerization (ATRP) methods were developed in water-based media, to grow polymers from proteins under biologically relevant conditions. These conditions gave good control over the resulting polymer, while still preserving the native structure. Several reaction parameters, such as ligand structure, halide species, and initiation mode were optimized in water and pas buffer to yield well-defined polymers grown from bovine serum albumin (BSA), functionalized with cleavable ATRP initiators (I). The CuCl complex with ligand 2,2'-bipyridyne (bpy) provides the best conditions for the polymerization of oligo(ethylene oxide) Methacrylate (OEOMA) in water at 30 degrees C under normal. ATRP conditions (I/CuCl/CuCl2/bpy = 1/1/9/22), while the CuBr/bpy complex gave better performance in PBS. Activators generated by electron transfer (AGET) ATRP gave well-controlled polymerization of OEOMA at 30 degrees C with the ligand tris(2-pyridylmethyl)amine (TPMA), (I/CuBr2/TpMA = 1/10/11). The AGET ATRP reactions required slow feeding of a very small amount of ascorbic acid into the aqueous reaction medium or buffer. The reaction conditions developed were used to create a smart, thermoresponsive, protein-polymer, hybrid.
机构:
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Boyer, Cyrille
;
Huang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Huang, Xin
;
Whittaker, Michael R.
论文数: 0引用数: 0
h-index: 0
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Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Whittaker, Michael R.
;
Bulmus, Volga
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Bulmus, Volga
;
Davis, Thomas P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
机构:Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Broyer, Rebecca M.
;
Grover, Gregory N.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Grover, Gregory N.
;
Maynard, Heather D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
机构:
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Boyer, Cyrille
;
Huang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Huang, Xin
;
Whittaker, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Whittaker, Michael R.
;
Bulmus, Volga
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
Bulmus, Volga
;
Davis, Thomas P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Sch Chem Engn, CAMD, Sydney, NSW 2052, AustraliaUniv New S Wales, Sch Biotechnol & Biomol Sci, CAMD, Sydney, NSW 2052, Australia
机构:Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Broyer, Rebecca M.
;
Grover, Gregory N.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Grover, Gregory N.
;
Maynard, Heather D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA