Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene

被引：60

作者：

Hata, S

Koyama, AH

Shiota, H

Adachi, A

Goshima, F

Nishiyama, Y ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Virol Lab, Dis Mechanism & Control Res Inst, Nagoya, Aichi 4668550, Japan

[2] Univ Tokushima, Sch Med, Dept Virol, Tokushima 7708503, Japan

[3] Univ Tokushima, Sch Med, Dept Ophthalmol, Tokushima 7708503, Japan

来源：

MICROBES AND INFECTION | 1999年 / 1卷 / 08期

基金：

日本学术振兴会;

关键词：

herpes simplex virus; apoptosis; antiapoptosis; protein kinase;

D O I：

10.1016/S1286-4579(99)80059-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to determine the ability of herpes simplex virus type 2 (HSV-2) to suppress apoptosis, we examined the effect of HSV-2 infection on apoptosis induced in HEp-2 cells by treatment with 1 M sorbitol. Although a wild-type strain of HSV-2 induced apoptosis in a significant fraction of the infected cells, HSV-2 could suppress sorbitol-induced apoptosis in a manner similar to that of herpes simplex virus type 1 (HSV-1), indicating that HSV-2, like HSV-1, has an antiapoptosis gene. Characterization of the cells infected with a US3-deletion mutant of HSV-2 revealed the necessity of a US3 gene in the antiapoptotic activity of this virus. (C) Elsevier, Paris.

引用

页码：601 / 607

页数：7

共 21 条

[1] THE GAMMA-134.5 GENE OF HERPES-SIMPLEX VIRUS-1 PRECLUDES NEUROBLASTOMA-CELLS FROM TRIGGERING TOTAL SHUTOFF OF PROTEIN-SYNTHESIS CHARACTERISTIC OF PROGRAMMED CELL-DEATH IN NEURONAL CELLS [J].