Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

被引：306

作者：

Daye, Dania ^{[1
,2
]}

Wellen, Kathryn E. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Canc Biol, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 04期

关键词：

Glutamine; Metabolism; Cancer; Glucose; Myc; Oxidative phosphorylation; ALPHA-KETOGLUTARATE; IDH2; MUTATIONS; CELL-GROWTH; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; INTERACTING PROTEIN; NMR MEASUREMENTS; GLUCOSE; EXPRESSION; SURVIVAL; PROLIFERATION;

D O I：

10.1016/j.semcdb.2012.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Increased glutaminolysis is now recognized as a key feature of the metabolic profile of cancer cells, along with increased aerobic glycolysis (the Warburg effect). In this review, we discuss the roles of glutamine in contributing to the core metabolism of proliferating cells by supporting energy production and biosynthesis. We address how oncogenes and tumor suppressors regulate glutamine metabolism and how cells coordinate glucose and glutamine as nutrient sources. Finally, we highlight the novel therapeutic and imaging applications that are emerging as a result of our improved understanding of the role of glutamine metabolism in cancer. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：362 / 369

页数：8

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