Poorer physical fitness is associated with reduced structural brain integrity in heart failure

被引：25

作者：

Alosco, Michael L. ^{[1
]}

Brickman, Adam M. ^{[2
]}

Spitznagel, Mary Beth ^{[1
,3
]}

Griffith, Erica Y. ^{[2
]}

Narkhede, Atul ^{[2
]}

Raz, Naftali ^{[4
]}

Cohen, Ronald ^{[5
,6
,7
]}

Sweet, Lawrence H. ^{[8
]}

Colbert, Lisa H. ^{[9
]}

Josephson, Richard ^{[10
,11
,12
,13
]}

Hughes, Joel ^{[1
,3
]}

Rosneck, Jim ^{[3
]}

Gunstad, John ^{[1
,3
]}

机构：

[1] Kent State Univ, Dept Psychol, Kent, OH 44242 USA

[2] Columbia Univ Coll Phys & Surg, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA

[3] Akron City Hosp, Summa Hlth Syst, Dept Psychiat, Akron, OH USA

[4] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA

[5] Univ Florida, Dept Neurol, Gainesville, FL USA

[6] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA

[7] Univ Florida, McKnight Brain Inst, Ctr Cognit Aging & Memory, Gainesville, FL USA

[8] Univ Georgia, Dept Psychol, Atlanta, GA USA

[9] Univ Wisconsin, Dept Kinesiol, Madison, WI USA

[10] Univ Hosp Cleveland, Case Med Ctr, Cleveland, OH 44106 USA

[11] Dept Med, Cleveland, OH USA

[12] Harrington Heart & Vasc Inst, Cleveland, OH USA

[13] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2013年 / 328卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Brain; Cognitive function; Heart failure; Neuroimaging; Physical fitness; VENTRICULAR EJECTION FRACTION; WHITE-MATTER-HYPERINTENSITIES; HUMAN CEREBRAL-CORTEX; COGNITIVE IMPAIRMENT; OLDER-ADULTS; CARDIORESPIRATORY FITNESS; CAPACITY; NEUROGENESIS; DYSFUNCTION; DEPRESSION;

D O I：

10.1016/j.jns.2013.02.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Physical fitness is an important correlate of structural and functional integrity of the brain in healthy adults. In heart failure (HF) patients, poor physical fitness may contribute to cognitive dysfunction and we examined the unique contribution of physical fitness to brain structural integrity among patients with HF. Methods: Sixty-nine HF patients performed the Modified Mini Mental State examination (3MS) and underwent brain magnetic resonance imaging. All participants completed the 2-minute step test (2MST), a brief measure of physical fitness. We examined the associations between cognitive performance, physical fitness, and three indices of global brain integrity: total cortical gray matter volume, total white matter volume, and whole brain cortical thickness. Results: Regression analyses adjusting for demographic characteristics, medical variables (e.g., left ventricular ejection fraction), and intracranial volume revealed reduced performance on the 2MST were associated with decreased gray matter volume and thinner cortex (p<.05). Follow up analyses showed that reduced gray matter volume and decreased cortical thickness were associated with poorer 3MS scores (p<.05). Conclusions: Poor physical fitness is common in HF and associated with reduced structural brain integrity. Prospective studies are needed to elucidate underlying mechanisms for the influence of physical fitness on brain health in HF. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：51 / 57

页数：7

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