High Divergence within the Major HIV Type 1 Subtype B Epidemic in Panama

被引：9

作者：

Ahumada-Ruiz, Sara ^{[1
,2
]}

Casado, Concepcion ^{[1
]}

Toala-Gonzalez, Ivan ^{[3
]}

Flores-Figueroa, Dario ^{[3
]}

Rodriguez-French, Amalia ^{[4
]}

Lopez-Galindez, Cecilio ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Virol Mol, Madrid 28220, Spain

[2] Univ Panama, Lab Microbiol Expt Aplicada, Panama City, Panama

[3] Complejo Hosp Dr Arnulfo Arias Madrid, Panama City, Panama

[4] Hosp Santo Tomas, Panama City, Panama

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2008年 / 24卷 / 11期

关键词：

D O I：

10.1089/aid.2008.0153

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The first molecular epidemiology study of human immunodeficiency virus type 1 (HIV-1) in Panama has been performed with plasma samples from 66 AIDS patients infected by different transmission routes and obtained from distinct locations. All samples were amplified by RT-PCR and sequenced in gag (p17) and env (C2-C4) genes. Phylogenetic analyses revealed that 64 (97%) of the samples belong to subtype B. We also identified the presence of two CRF, one CRF12_BF and one CRF02_AG. The most notable feature of the subtype B epidemic in Panama was the large genetic distance among isolates with a mean of 15.2% but reaching up to 31.3% in env, indicating an epidemic with a long period of evolution.

引用

页码：1461 / 1466

页数：6

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