Herpes Zoster and Postherpetic Neuralgia in Older Adults

被引：48

作者：

Schmader, Kenneth ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Div Geriatr, Durham, NC 27710 USA

[3] Durham Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr 182, Durham, NC 27705 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2007年 / 23卷 / 03期

关键词：

D O I：

10.1016/j.cger.2007.03.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Herpes zoster (HZ) afflicts millions of older adults annually and causes significant suffering from acute and chronic pain, or postherpetic neuralgia (PHN). HZ is caused by the reactivation of varicella-zoster virus (VZV) in sensory ganglia in the setting of age, disease, and drug-related decline in cellular immunity. VZV-induced neuronal destruction and inflammation cause the pain, interference with activities of daily living, and reduced quality of life. The optimal treatment of HZ requires early antiviral therapy and pain management. For PHN, evidence-based pharmacotherapy can reduce pain burden. The zoster vaccine is effective in reducing pain burden and preventing HZ and PHN in older adults.

引用

页码：615 / +

页数：20

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