One-step exchange-labelling of pyridines and other N-heteroaromatics using deuterium gas:: catalysis by heterogeneous rhodium and ruthenium catalysts

被引：35

作者：

Alexakis, Efstathios ^{[1
]}

Jones, John R. ^{[1
]}

Lockley, William J. S. ^{[1
]}

机构：

[1] Univ Surrey, Sch Biomed & Mol Sci, Guildford GU2 7XH, Surrey, England

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 29期

基金：

英国工程与自然科学研究理事会;

关键词：

pyridine; N-heteroaromatic; alpha-exchange; deuteration; tritiation; ruthenium black; rhodium black; rhodium on alumina; isotope-exchange; deuterium gas;

D O I：

10.1016/j.tetlet.2006.05.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of pyridines and other nitrogen heteroaromatics can be labelled with deuterium at room temperature and pressure by isotopic exchange with deuterium gas in THF in the presence of rhodium black, ruthenium black or 5% rhodium on alumina. The labelling is rapid, isotope efficient and applicable to both electron-rich and electron-poor substrates. In a few cases, a degree of reduction accompanies the exchange. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5025 / 5028

页数：4

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