Ligand effects upon deuterium exchange in arenes mediated by [Ir(PR3)2(cod)]+•BF4-

被引：33

作者：

Ellames, GJ

Gibson, JS

Herbert, JM

Kerr, WJ

McNeill, AH

机构：

[1] Sanofi Synthelabo, Isotope Chem & Metabolite Synth Dept, Alnwick NE66 2JH, Northd, England

[2] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2004年 / 47卷 / 01期

关键词：

iridium complexes; isotope exchange; ortho-deuteration; ligand effects;

D O I：

10.1002/jlcr.790

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of complexes of general form [Ir(PR3)(2)(cod)](+) has been prepared and used, without isolation, to mediate deuteration of a range of model substrates. The data suggest that, with many substrates, basicity of the phosphine ligands bound to iridium is an important factor influencing substrate selectivity and the efficiency of deuteration. In addition, the spectrum of activity of iridium complexes bearing pure donor ligands is different in many cases to that of complexes where the ligands are known to be pi-acids. Copyright (C) 2003 John Wiley Sons, Ltd.

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页码：1 / 10

页数：10

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