Diffusion Tensor Imaging of Sports-Related Concussion in Adolescents

被引:72
作者
Virji-Babul, Naznin [1 ,2 ]
Borich, Michael R. [1 ]
Makan, Nadia [1 ]
Moore, Tiffany [1 ]
Frew, Kira [1 ]
Emery, Carolyn A. [3 ,4 ]
Boyd, Lara A. [1 ]
机构
[1] Univ British Columbia, Dept Phys Therapy, Vancouver, BC V6T 1Z3, Canada
[2] Child & Family Res Inst, Vancouver, BC, Canada
[3] Univ Calgary, Fac Kinesiol, Sport Injury Prevent Res Ctr, Calgary, AB, Canada
[4] Univ Calgary, Fac Med, Alberta Childrens Hosp Res Inst Child & Maternal, Calgary, AB, Canada
关键词
TRAUMATIC BRAIN-INJURY; HEAD-INJURY; ANISOTROPY; CHILDREN; LESIONS; STROKE;
D O I
10.1016/j.pediatrneurol.2012.09.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Concussion is among the least understood neurologic injuries. The impact of concussion on the adolescent brain remains largely unknown. This study sought to establish short-term changes in white-matter integrity after sports-related concussion in adolescents, and examine the association between changes in white-matter integrity and a clinical measure of concussion. Twelve adolescents, aged 14-17 years with a sports-related concussion within 2 months, and 10 age-matched adolescents with no history of concussion were evaluated with the Sports Concussion Assessment Tool 2 and diffusion tensor imaging. Two measures compared the two groups: fractional anisotropy and mean diffusivity. Whole-brain fractional anisotropy values significantly increased (F(1,40) = 6.29, P = 0.010), and mean diffusivity values decreased (F(1,40) = 4.75, P = 0.036), in concussed athletes compared with control participants. Total scores on the Sports Concussion Assessment Tool 2 were associated with whole-brain fractional anisotropy. Mean diffusivity values with lower scores were associated with higher fractional anisotropy (R-2 = 0.25, P = 0.017) and lower mean diffusivity (R-2 = 0.20, P = 0.038). We provide evidence of structural changes in the integrity of white matter in adolescent athletes after sports-related concussion. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:24 / 29
页数:6
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