He-3-MRI of pulmonary ventilation: First clinical applications.

Purpose of the study is the visualisation of normal pulmonary ventilation in healthy volunteers and the evaluation of abnormalities in patients with different lung diseases using He-3 magnetic resonance imaging (He-3 - MRI). Material and methods: Hyperpolarised He-3 gas (V = 300 ml, p = 3 x 10(5) Pa, polarised to 35-45% by optical pumping, provided in special glass cells) was inhaled by eight healthy volunteers and ten patients with different lung diseases. A 3D FLASH sequence (T-R = 11.8 ms; T-E = 5 ms; matrix 144 x 256, FOV 350 mm, section thickness 7 - 10 mm, coronal orientation) was performed in a single breath-hold (22 - 42 s). Clinical and radiological examinations were available for correlation. Results: The studies were successfully carried out in 8/8 volunteers and in 8/10 patients. The central airways were constantly visualised with intermediate to high signal intensity. The lung parenchyma of volunteers with normal ventilatory function showed Father homogeneous intermediate to high signal, whereas patients with chronic obstructive lung disease and/or pneumonia presented severe signal inhomogeneitises. Space-occupying lesions and pleural effusion caused large areas with little or no signal. The represented the lesion and adjacent ventilatory disturbances whose extent had not been presumed from chest x-ray or CT. The spatial resolution was higher than in Ventilation scintigraphy. Conclusion: He-3 MRI is a promising new modality for the assessment of pulmonary ventilation and its anomalies.