How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2

被引：48

作者：

Prehoda, KE

Lim, WA

机构：

[1] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[2] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA

[3] Univ Oregon, Dept Chem, Eugene, OR 97403 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(02)00307-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties, Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.

引用

页码：149 / 154

页数：6

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