Arachidonic acid and ion channels: an update

被引：126

作者：

Meves, H. ^{[1
]}

机构：

[1] Univ Saarland, Inst Physiol, D-66421 Homburg, Germany

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2008年 / 155卷 / 01期

关键词：

arachidonic acid; ion channels; leukotrienes; prostaglandins; TRP channels; SOCE channels;

D O I：

10.1038/bjp.2008.216

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Arachidonic acid (AA), a polyunsaturated fatty acid with four double bonds, has multiple actions on living cells. Many of these effects are mediated by an action of AA or its metabolites on ion channels. During the last 10 years, new types of ion channels, transient receptor potential (TRP) channels, store-operated calcium entry (SOCE) channels and non-SOCE channels have been studied. This review summarizes our current knowledge about the effects of AA on TRP and non-SOCE channels as well as classical ion channels. It aims to distinguish between effects of AA itself and effects of AA metabolites. Lipid mediators are of clinical interest because some of them (for example, leukotrienes) play a role in various diseases, others (such as prostaglandins) are targets for pharmacological therapeutic intervention.

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页码：4 / 16

页数：13

相关论文

共 176 条

[1]

ALICIA S, 2008, CELL CA

[2] Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals [J].

Allen, NJ ;

Attwell, D .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 543 (02) :521-529

[3] Potentiation of native and recombinant P2X7-mediated calcium signaling by arachidonic acid in cultured cortical astrocytes and human embryonic kidney 293 cells [J].

Alloisio, Susanna ;

Aiello, Rita ;

Ferroni, Stefano ;

Nobile, Mario .

MOLECULAR PHARMACOLOGY, 2006, 69 (06) :1975-1983

[4] Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids [J].

Andersson, David A. ;

Nash, Mark ;

Bevan, Stuart .

JOURNAL OF NEUROSCIENCE, 2007, 27 (12) :3347-3355

[5] Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice [J].

Andoh, T ;

Kuraishia, Y .

MOLECULAR BRAIN RESEARCH, 2005, 137 (1-2) :263-266

[6] Oxidative modulation of the transient potassium current IA by intracellular arachidonic acid in rat CA1 pyramidal neurons [J].

Angelova, Plamena ;

Mueller, Wolfgang .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 23 (09) :2375-2384

[7] Leukotriene B4 signaling through NF-κB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia [J].

Bäck, M ;

Bu, DX ;

Bränström, R ;

Sheikine, Y ;

Yan, ZQ ;

Hansson, GK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (48) :17501-17506

[8] Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin [J].

Bandell, M ;

Story, GM ;

Hwang, SW ;

Viswanath, V ;

Eid, SR ;

Petrus, MJ ;

Earley, TJ ;

Patapoutian, A .

NEURON, 2004, 41 (06) :849-857

[9] TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family [J].

Bang, H ;

Kim, Y ;

Kim, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17412-17419

[10] Arachidonic acid reversibly enhances N-type calcium current at an extracellular site [J].

Barrett, CF ;

Liu, LW ;

Rittenhouse, AR .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 280 (05) :C1306-C1318

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