Development of miltefosine for the leishmaniases

被引：30

作者：

Berman, JD ^{[1
]}

机构：

[1] NIH, Natl Ctr Complementary & Alternat Med, Bethesda, MD 20892 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 02期

关键词：

miltefosine; visceral leishmaniasis; cutaneous leishmaniasis; efficacy; tolerance;

D O I：

10.2174/138955706775475993

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The leishmaniases consist of visceral and cutaneous syndromes present in > 30 endemic regions of the world. Miltefosine (hexadecylephosphocholine) is the first oral agent that is effective and tolerated for both visceral and cutaneous disease in several endemic regions, and represents a major advance in the treatment of these diseases.

引用

页码：145 / 151

页数：7

共 36 条

[1] CYTOTOXICITY OF ESTER AND ETHER LYSOPHOSPHOLIPIDS ON LEISHMANIA-DONOVANI PROMASTIGOTES [J].

ACHTERBERG, V ;

GERCKEN, G .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 23 (02) :117-122

[2] METABOLISM OF ETHER LYSOPHOSPHOLIPIDS IN LEISHMANIA-DONOVANI PROMASTIGOTES [J].

ACHTERBERG, V ;

GERCKEN, G .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 26 (03) :277-287

[3]

[Anonymous], 2001, Clin Infect Dis

[4] Leishmanicidal activity of edelfosine, miltefosine and ilmofosine [J].

Azzouz, S ;

Maache, M ;

Garcia, RG ;

Osuna, A .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 96 (01) :60-65

[5] Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India [J].

Bhattacharya, SK ;

Jha, TK ;

Sundar, S ;

Thakur, CP ;

Engel, J ;

Sindermann, H ;

Junge, K ;

Karbwang, J ;

Bryceson, ADM ;

Berman, JD .

CLINICAL INFECTIOUS DISEASES, 2004, 38 (02) :217-221

[6] The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei [J].

Croft, SL ;

Snowdon, D ;

Yardley, V .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 (06) :1041-1047

[7] Antiprotozoal activities of phospholipid analogues [J].

Croft, SL ;

Seifert, K ;

Duchêne, M .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 126 (02) :165-172

[8] THE ACTIVITY OF ALKYL PHOSPHORYLCHOLINES AND RELATED DERIVATIVES AGAINST LEISHMANIA-DONOVANI [J].

CROFT, SL ;

NEAL, RA ;

PENDERGAST, W ;

CHAN, JH .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (16) :2633-2636

[9] Antiprotozoal lysophospholipid analogues: A comparison of their activity against trypanosomatid parasites and tumor cells [J].

de Castro, SL ;

Santa-Rita, RM ;

Urbina, JA ;

Croft, SL .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2004, 4 (02) :141-151

[10] TOPICAL ADMINISTRATION OF HEXADECYLPHOSPHOCHOLINE IN PATIENTS WITH CUTANEOUS LYMPHOMAS - RESULTS OF A PHASE-I/II STUDY [J].

DUMMER, R ;

KRASOVEC, M ;

ROGER, J ;

SINDERMANN, H ;

BURG, G .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1993, 29 (06) :963-970

← 1 2 3 4 →