Effects of aging on motor cortex excitability

被引：239

作者：

Oliviero, A

Profice, P

Tonali, PA

Pilato, F

Saturno, E

Dileone, M

Ranieri, F

Di Lazzaro, V

机构：

[1] Hosp Nacl Paraplej, FENNSI Grp, SESCAM, Toledo 45071, Spain

[2] Univ Cattolica Rome, Neurol Inst, I-00168 Rome, Italy

来源：

NEUROSCIENCE RESEARCH | 2006年 / 55卷 / 01期

关键词：

aging; transcranial magnetic stimulation; GABA; motor cortex;

D O I：

10.1016/j.neures.2006.02.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine whether aging is associated with changes in excitability of the cerebral cortex, we evaluated the excitability of the motor cortex with transcranial magnetic stimulation (TMS). We compared TMS related measures obtained in a group of young people with those of a group of old people. Motor evoked potential (MEP) amplitude was significantly smaller in older than in younger controls (1.3 +/- 0.8 mV versus 2.7 +/- 1.1 mV; p < 0.0071). Mean cortical silent period (CSP) duration was shorter in older than in younger controls (87 +/- 29 ms versus 147 +/- 39 ins; p < 0.0071). SP duration/MEP amplitude ratios were similar in both groups. Our results are consistent with an impaired efficiency of some intracortical circuits in old age. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

收藏

页码：74 / 77

页数：4

相关论文

共 20 条

[11] Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex [J].

Peinemann, A ;

Lehner, C ;

Conrad, B ;

Siebner, HR .

NEUROSCIENCE LETTERS, 2001, 313 (1-2) :33-36

[12] Age and sex differences in human motor cortex input-output characteristics [J].

Pitcher, JB ;

Ogston, KM ;

Miles, TS .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (02) :605-613

[13] NONINVASIVE ELECTRICAL AND MAGNETIC STIMULATION OF THE BRAIN, SPINAL-CORD AND ROOTS - BASIC PRINCIPLES AND PROCEDURES FOR ROUTINE CLINICAL-APPLICATION - REPORT OF AN IFCN COMMITTEE [J].

ROSSINI, PM ;

BARKER, AT ;

BERARDELLI, A ;

CARAMIA, MD ;

CARUSO, G ;

CRACCO, RQ ;

DIMITRIJEVIC, MR ;

HALLETT, M ;

KATAYAMA, Y ;

LUCKING, CH ;

DENOORDHOUT, ALM ;

MARSDEN, CD ;

MURRAY, NMF ;

ROTHWELL, JC ;

SWASH, M ;

TOMBERG, C .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1994, 91 (02) :79-92

[14] AGE-RELATED-CHANGES OF MOTOR EVOKED-POTENTIALS IN HEALTHY HUMANS - NONINVASIVE EVALUATION OF CENTRAL AND PERIPHERAL MOTOR TRACTS EXCITABILITY AND CONDUCTIVITY [J].

ROSSINI, PM ;

DESIATO, MT ;

CARAMIA, MD .

BRAIN RESEARCH, 1992, 593 (01) :14-19

[15] Critical decline in fine motor hand movements in human aging [J].

Smith, CD ;

Umberger, GH ;

Manning, EL ;

Slevin, JT ;

Wekstein, DR ;

Schmitt, FA ;

Markesbery, WR ;

Zhang, Z ;

Gerhardt, GA ;

Kryscio, RJ ;

Gash, DM .

NEUROLOGY, 1999, 53 (07) :1458-1461

[16] Short latency inhibition of human hand motor cortex by somatosensory input from the hand [J].

Tokimura, H ;

Di Lazzaro, V ;

Tokimura, Y ;

Oliviero, A ;

Profice, P ;

Insola, A ;

Mazzone, P ;

Tonali, P ;

Rothwell, JC .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 (02) :503-513

[17] Age-related changes in the neural correlates of motor performance [J].

Ward, NS ;

Frackowiak, RSJ .

BRAIN, 2003, 126 :873-888

[18] Variation in the response to transcranial magnetic brain stimulation in the general population [J].

Wassermann, EM .

CLINICAL NEUROPHYSIOLOGY, 2002, 113 (07) :1165-1171

[19] Dextromethorphan decreases the excitability of the human motor cortex [J].

Ziemann, U ;

Chen, R ;

Cohen, LG ;

Hallett, M .

NEUROLOGY, 1998, 51 (05) :1320-1324

[20] Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study [J].

Ziemann, U ;

Lonnecker, S ;

Steinhoff, BJ ;

Paulus, W .

ANNALS OF NEUROLOGY, 1996, 40 (03) :367-378